CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007893
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-4 
Protein Synonyms/Alias
 Autophagy-related protein 24; Cytoplasm to vacuole targeting protein 13 
Gene Name
 SNX4 
Gene Synonyms/Alias
 ATG24; CVT13; YJL036W; J1244 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
396VKTAEIKKSLGSLADubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). Involved in retrieval of late-Golgi SNAREs from post- Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy. Involved in proper sorting of the v-SNARE protein SNC1. 
Sequence Annotation
 DOMAIN 29 157 PX.
 BINDING 78 78 Phosphatidylinositol 3-phosphate (By
 BINDING 80 80 Phosphatidylinositol 3-phosphate; via
 BINDING 104 104 Phosphatidylinositol 3-phosphate (By
 BINDING 123 123 Phosphatidylinositol 3-phosphate (By  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MTDKGKNDLT SKAKDKARGN PEKPPYWFEI IVSDPQKRTG DPGSSSGYVS YQISTKTNNT 60
SFYDNRGDPE SIIVVHRRYS DLLLLHDILL NRFPTCIIPP LPDKKVFQYI AGDRFSQRFT 120
QKRCHSLQNF LRRVSLHPDL SQSKVFKTFL VSKDWESHRK VLQDSLQPNK DEVTDAFMNA 180
FKTVHKQNEE FTEIREKSDK LDRTVTKIDK LFHKVVKKND SMSEDYTKLG SNLQELQELV 240
TGENEELAAK LKIFNEGVTQ LSYGLQDLTK YLDYEYIVDL KDLEHYIDSM RQLIKLKDQK 300
QIDYEELSDY LTRSIKEKNN LISGYGGSNF FANKLEELAG INQEASRREK INKLEGKITS 360
LTGELENAKK VADGFEQECL KEIDHFESVK TAEIKKSLGS LADHHIEFYE RILEAWEKVD 420
DSL 423 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005769; C:early endosome; IDA:SGD.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0000407; C:pre-autophagosomal structure; IDA:SGD.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0032258; P:CVT pathway; IMP:SGD.
 GO:0034498; P:early endosome to Golgi transport; IMP:SGD.
 GO:0000422; P:mitochondrion degradation; IMP:SGD.
 GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD. 
Interpro
 IPR001683; Phox. 
Pfam
 PF00787; PX 
SMART
 SM00312; PX 
PROSITE
 PS50195; PX 
PRINTS