CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019100
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phospholipase D4 
Protein Synonyms/Alias
 PLD 4; Choline phosphatase 4; Phosphatidylcholine-hydrolyzing phospholipase D4 
Gene Name
 PLD4 
Gene Synonyms/Alias
 C14orf175; UNQ2488/PRO5775 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
271YWVLGVPKAVLPKTWubiquitination[1]
276VPKAVLPKTWPQNFSubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
 DOMAIN 209 236 PLD phosphodiesterase 1.
 DOMAIN 423 449 PLD phosphodiesterase 2.
 ACT_SITE 214 214 Potential.
 ACT_SITE 216 216 Potential.
 ACT_SITE 221 221 Potential.  
Keyword
 Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 506 AA 
Protein Sequence
MLKPLWKAAV APTWPCSMPP RRPWDREAGT LQVLGALAVL WLGSVALICL LWQVPRPPTW 60
GQVQPKDVPR SWEHGSSPAW EPLEAEARQQ RDSCQLVLVE SIPQDLPSAA GSPSAQPLGQ 120
AWLQLLDTAQ ESVHVASYYW SLTGPDIGVN DSSSQLGEAL LQKLQQLLGR NISLAVATSS 180
PTLARTSTDL QVLAARGAHV RQVPMGRLTR GVLHSKFWVV DGRHIYMGSA NMDWRSLTQV 240
KELGAVIYNC SHLAQDLEKT FQTYWVLGVP KAVLPKTWPQ NFSSHFNRFQ PFHGLFDGVP 300
TTAYFSASPP ALCPQGRTRD LEALLAVMGS AQEFIYASVM EYFPTTRFSH PPRYWPVLDN 360
ALRAAAFGKG VRVRLLVGCG LNTDPTMFPY LRSLQALSNP AANVSVDVKV FIVPVGNHSN 420
IPFSRVNHSK FMVTEKAAYI GTSNWSEDYF SSTAGVGLVV TQSPGAQPAG ATVQEQLRQL 480
FERDWSSRYA VGLDGQAPGQ DCVWQG 506 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0070290; F:NAPE-specific phospholipase D activity; IEA:EC.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:Reactome.
 GO:0004630; F:phospholipase D activity; IEA:EC.
 GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0006655; P:phosphatidylglycerol biosynthetic process; TAS:Reactome. 
Interpro
 IPR001736; PLipase_D/transphosphatidylase. 
Pfam
  
SMART
 SM00155; PLDc 
PROSITE
 PS50035; PLD 
PRINTS