CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTPase NRas 
Protein Synonyms/Alias
 Transforming protein N-Ras 
Gene Name
 Nras 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
128PTRTVDTKQAHELAKubiquitination[1]
147PFIETSAKTRQGVEDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. 
Sequence Annotation
 NP_BIND 10 17 GTP.
 NP_BIND 57 61 GTP.
 NP_BIND 116 119 GTP.
 REGION 166 185 Hypervariable region.
 MOTIF 32 40 Effector region.
 MOD_RES 186 186 Cysteine methyl ester (By similarity).
 LIPID 181 181 S-palmitoyl cysteine (By similarity).
 LIPID 186 186 S-farnesyl cysteine (By similarity).  
Keyword
 Acetylation; Cell membrane; Complete proteome; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Prenylation; Proto-oncogene; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 189 AA 
Protein Sequence
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 60
QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL 120
PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRLKK LNSSDDGTQG 180
CMGSPCVLM 189 
Gene Ontology
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:MGI.
 GO:0007265; P:Ras protein signal transduction; TAS:MGI.
 GO:0051726; P:regulation of cell cycle; TAS:MGI. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 
Pfam
 PF00071; Ras 
SMART
 SM00173; RAS 
PROSITE
 PS51421; RAS 
PRINTS
 PR00449; RASTRNSFRMNG.