CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033480
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphoribosylaminoimidazolecarboxamide formyltransferase 
Protein Synonyms/Alias
  
Gene Name
 ATIC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MLGGRVKTLHPAVHubiquitination[1, 2, 3, 4, 5]
118TRRQLALKAFTHTAQubiquitination[1, 4, 5]
140YFRKQYSKGVSQMPLubiquitination[1, 4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 170 AA 
Protein Sequence
MLGGRVKTLH PAVHAGILAR NIPEDNADMA RLDFNLIRVV ACNLYPFVKT VASPGVTVEE 60
AVEQIDIGGV TLLRAAAKNH ARVTVVCEPE DYVVVSTEMQ SSESKDTSLE TRRQLALKAF 120
THTAQYDEAI SDYFRKQYSK GVSQMPLRYG MNPHQTPAQL YTLQPKLPIT 170 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0003937; F:IMP cyclohydrolase activity; IEA:Compara.
 GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:Compara.
 GO:0003360; P:brainstem development; IEA:Compara.
 GO:0021549; P:cerebellum development; IEA:Compara.
 GO:0021987; P:cerebral cortex development; IEA:Compara.
 GO:0046452; P:dihydrofolate metabolic process; IEA:Compara.
 GO:0009116; P:nucleoside metabolic process; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
 GO:0010035; P:response to inorganic substance; IEA:Compara.
 GO:0009259; P:ribonucleotide metabolic process; IEA:Compara.
 GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:Compara. 
Interpro
 IPR002695; AICARFT_IMPCHas.
 IPR011607; MGS-like_dom. 
Pfam
 PF01808; AICARFT_IMPCHas
 PF02142; MGS 
SMART
 SM00851; MGS 
PROSITE
  
PRINTS