CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027041
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Structural maintenance of chromosomes protein 
Protein Synonyms/Alias
  
Gene Name
 SMC2 
Gene Synonyms/Alias
 CG10212; Dmel_CG10212 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
238IRIHISAKYLKQCETacetylation[1]
255TVEANEHKIEDRIANacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1179 AA 
Protein Sequence
MYVKKLVLDG FKSYGRRTEI EGFDPEFTAI TGLNGSGKSN ILDSICFVLG ISNLQNVRAS 60
ALQDLVYKNG QAGITKATVT IVFDNTNPAQ CPQGYEKCRE ISVTRQVVVG GKNKFLINGK 120
LVQNKKVQDF FCSIQLNVNN PNFLIMQGKI QQVLNMKPKE VLSMVEEAAG TSQYKTKRDA 180
TKTLIEKKET KVRETKVLLD EEVLPKLVKL RQERSAYQEY QKICRDIDFL IRIHISAKYL 240
KQCETLKTVE ANEHKIEDRI ANCKATHAKN LAEVESIENS VKEMQQQIDA EMGGSIKNLE 300
TQLSAKRALE ATATGSLKAA QGTIQQDEKK IRMASKNIED DERALAKKEA DMAKVQGEFE 360
SLKEADARDS KAYEDAQKKL EAVSQGLSTN ENGEASTLQE QLIVAKEQFS EAQTTIKTSE 420
IELRHTRGVL KQREGETQTN DAAYVKDKKL HDQLVVEIKN LERQLQSLDY EGGHFEKLKQ 480
RRNDLHMRKR DLKRELDRCN ASRYDLQYQD PEPNFDRRKV RGLVGKLFQV KDMQNSMALV 540
QTAGGSLYSY VTDDDVTSKK ILQRGNLQRR VTLIPINKIQ SGSLNRNVVE YAQNKVGAEN 600
VQWAMSLIDY DRYYEPVMKF CFGGTLICKD LIVAKQISYD PRINCRSVTL EGDVVDPHGT 660
VSGGAAPKGA NVLEELHAIK QIEKEYREID SEIAQVEKQI ASIENQALAF NKMKENLDLR 720
QHELTMCENR LAQTTFQQNQ AEIEEMRERV KTLEQQIIDS REKQKTSQAK IVDIEAKLAD 780
AKGYRERELN AATNEIKVTK QRAEKSRANW KKREQEFETL QLEITELQKS IETAKKQHQE 840
MIDNLEKFKA ELDALKVNSS SAASEVTELE QAIKEQKDKL RDQNKEMRNQ LVKKEKMLKE 900
NQEIELEVKK KENEQKKISS DAKEAKKRME ALEAKYPWIP EEKNCFGMKN TRYDYSKEDP 960
HEAGNKLAKM QEKKDKMERT LNMNAIMVLD REEENFKETE RRRNIVAMDK EKIKKIIVKM 1020
DEEEQDQLNK AATEVNTNFS GIFSSLLPGA EAKLNPVHTN GCLTGLEIKV GFNGIWKESL 1080
GELSGGQKSL VALSLVLAML KFSPAPLYIL DEVDAALDMS HTQNIGSMLK QHFTNSQFLI 1140
VSLKDGLFNH ANVLFRTLFE EGVSTITRQV SRQATTNKR 1179 
Gene Ontology
 GO:0000796; C:condensin complex; NAS:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0007076; P:mitotic chromosome condensation; IMP:FlyBase.
 GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0007062; P:sister chromatid cohesion; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR003395; RecF/RecN/SMC.
 IPR024704; SMC.
 IPR027120; Smc2.
 IPR010935; SMC_hinge. 
Pfam
 PF06470; SMC_hinge
 PF02463; SMC_N 
SMART
 SM00968; SMC_hinge 
PROSITE
  
PRINTS