CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plectin 
Protein Synonyms/Alias
  
Gene Name
 Plec 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
67TFTKWVNKHLIKAQRacetylation[1]
473FNDVQTLKDGRHPQGacetylation[1]
678LMRELEMKEKKIKEIacetylation[1]
781LQDAQDEKEQLNEYKacetylation[1]
805AKAIVQLKPRNPAHPacetylation[1]
1139LQELEVTKASLKKLRacetylation[1]
1283EECQKFAKQYINAIKacetylation[1]
2525FIEQEKAKLEQLFQDacetylation[1]
2714SIAGLLLKPTNEKLSacetylation[1]
2964TGRITVEKIIKIVITacetylation[1]
3175YARGYLDKETNRALTacetylation[1]
3293TGKVTVEKVIKILITacetylation[1]
3342RTQFEQLKDGKTSVKacetylation[1]
3376GIYLEDSKEKVTIYEacetylation[1]
3841YQRGYLNKDTHDQLSacetylation[1]
4013VGPEFKDKLLSAERAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4557 AA 
Protein Sequence
SSNGSSGSPS PGDTLPWNLG KTQRSRRSGG GSVGNGSVLD PAERAVIRIA DERDRVQKKT 60
FTKWVNKHLI KAQRHISDLY EDLRDGHNLI SLLEVLSGDS LPREKGRMRF HKLQNVQIAL 120
DYLRHRQVKL VNIRNDDIAD GNPKLTLGLI WTIILHFQIS DIQVSGQSED MTAKEKLLLW 180
SQRMVEGYQG LRCDNFTTSW RDGRLFNAII HRHKPMLIDM NKVYRQTNLE NLDQAFSVAE 240
RDLGVTRLLD PEDVDVPQPD EKSIITYVSS LYDAMPRVPG AQDGVRANEL QLRWQEYREL 300
VLLLLQWIRH HTAAFEERKF PSSFEEIEIL WCQFLKFKET ELPAKEADKN RSKGIYQSLE 360
GAVQAGQLKI PPGYHPLDVE KEWGKLHVAI LEREKQLRSE FERLECLQRI VSKLQMEAGL 420
CEEQLNQADS LLQSDIRLLA SGKAAQRAGE VERDLDKADG MIRLLFNDVQ TLKDGRHPQG 480
EQMYRRVYRL HERLVAIRTE YNLRLKAGVG APVTQVTLQS TQRRPELEDS TLRYLHDLLA 540
WVEENQRRID GAEWGVDLPS VEAQLGSHRG MHQSIEEFRA KIERARNDES QLSPATRGAY 600
RDCLGRLDLQ YAKLLNSSKA RLRSLESLHG FVAAATKELM WLNEKEEEEV GFDWSDRNTN 660
MAAKKESYSA LMRELEMKEK KIKEIQNTGD RLLREDHPAR PTVESFQAAL QTQWSWMLQL 720
CCCIEAHLKE NTAYFQFFSD VREAEEQLQK LQETLRRKYS CDRSITVTRL EDLLQDAQDE 780
KEQLNEYKGH LSGLAKRAKA IVQLKPRNPA HPVRGHVPLL AVCDYKQVEV TVHKGDQCQL 840
VGPAQPFHWK VLGGSSSEAA VPSVCFLVPP PNQEAQEAVA RLEAQHQALV TLWHQLHVDM 900
KSLLAWQSLN RDIQLIRSWS LVTFRTLKPE EQRQALRNLE LHYQAFLRDS QDAGGFGPED 960
RLVAEREYGS CSRHYQQLLQ SLEQGEQEES RCQRCISELK DIRLQLEACE TRTVHRLRLP 1020
LDKDPARECA QRIAEQQKAQ AEVEGLGKGV ARLSAEAEKV LALPEPSPAA PTLRSELELT 1080
LGKLEQVRSL SAIYLEKLKT ISLVIRSTQG AEEVLKTHEE HLKEAQAVPA TLQELEVTKA 1140
SLKKLRAQAE AQQPVFNTLR DELRGAQEVG ERLQQRHGER DVEVERWRER VTQLLERWQA 1200
VLAQTDVRQR ELEQLGRQLR YYRESADPLS SWLQDAKSRQ EQIQAVPIAN SQAAREQLRQ 1260
EKALLEEIER HGEKVEECQK FAKQYINAIK DYELQLITYK AQLEPVASPA KKPKVQSGSE 1320
SVIQEYVDLR TRYSELTTLT SQYIKFISET LRRMEEEERL AEQQRAEERE RLAEVEAALE 1380
KQRQLAEAHA QAKAQAELEA RELQRRMQEE VTRREEAAVD AQQQKRSIQE ELQHLRQSSE 1440
AEIQAKAQQV EAAERSRMRI EEEIRVVRLQ LETTERQRGG AEDELQALRA RAEEAEAQKR 1500
QAQEEAERLR RQVQDESQRK RQAEAELALR VKAEAEAARE KQRALQALDE LKLQAEEAER 1560
RLRQAEAERA RQVQVALETA QRSAEVELQS KRASFAEKTA QLERTLQEEH VTVTQLREEA 1620
ERRAQQQAEA ERAREEAERE LERWQLKANE ALRLRLQAEE VAQQKSLAQA DAEKQKEEAE 1680
REARRRGKAE EQAVRQRELA EQELEKQRQL AEGTAQQRLA AEQELIRLRA ETEQGEQQRQ 1740
LLEEELARLQ HEATAATQKR QELEAELAKV RAEMEVLLAS KARAEEESRS TSEKSKQRLE 1800
AEAGRFRELA EEAARLRALA EEAKRQRQLA EEDAARQRAE AERVLTEKLA AISEATRLKT 1860
EAEIALKEKE AENERLRRLA EDEAFQRRRL EEQAAQHKAD IEERLAQLRK ASESELERQK 1920
GLVEDTLRQR RQVEEEIMAL KASFEKAAAG KAELELELGR IRSNAEDTMR SKELAEQEAA 1980
RQRQLAAEEE QRRREAEERV QRSLAAEEEA ARQRKVALEE VERLKAKVEE ARRLRERAEQ 2040
ESARQLQLAQ EAAQKRLQAE EKAHAFVVQQ REEELQQTLQ QEQNMLERLR SEAEAARRAA 2100
EEAEEAREQA EREAAQSRKQ VEEAERLKQS AEEQAQAQAQ AQAAAEKLRK EAEQEAARRA 2160
QAEQAALKQK QAADAEMEKH KKFAEQTLRQ KAQVEQELTT LRLQLEETDH QKSILDEELQ 2220
RLKAEVTEAA RQRSQVEEEL FSVRVQMEEL GKLKARIEAE NRALILRDKD NTQRFLEEEA 2280
EKMKQVAEEA ARLSVAAQEA ARLRQLAEED LAQQRALAEK MLKEKMQAVQ EATRLKAEAE 2340
LLQQQKELAQ EQARRLQEDK EQMAQQLVEE TQGFQRTLEA ERQRQLEMSA EAERLKLRMA 2400
EMSRAQARAE EDAQRFRKQA EEIGEKLHRT ELATQEKVTL VQTLEIQRQQ SDQDAERLRE 2460
AIAELEREKE KLKQEAKLLQ LKSEEMQTVQ QEQILQETQA LQKSFLSEKD SLLQRERFIE 2520
QEKAKLEQLF QDEVAKAKQL QEEQQRQQQQ MEQEKQELVA SMEEARRRQR EAEEGVRRKQ 2580
EELQRLEQQR QQQEKLLAEE NQRLRERLQR LEEEHRAALA HSEEIATSQA AATKALPNGR 2640
DALDGPSMEA EPEYTFEGLR QKVPAQQLQE AGILSMEELQ RLTQGHTTVA ELTQREDVHR 2700
YLKGGSSIAG LLLKPTNEKL SVYTALQRQL LSPGTALILL EAQAASGFLL DPVRNRRLTV 2760
NEAVKEGVVG PELHHKLLSA ERAVTGYKDP YTGEQISLFQ AMKKDLIVRD HGIRLLEAQI 2820
ATGGIIDPVH SHRVPVDVAY QRGYFDEEMN RVLADPSDDT KGFFDPNTHE NLTYLQLLER 2880
CVEDPETGLR LLPLTDKAAK GGELVYTDTE ARDVFEKATV SAPFGKFQGK TVTIWEIINS 2940
EYFTAEQRRD LLRQFRTGRI TVEKIIKIVI TVVEEHERKG QLCFEGLRAL VPAAELLDSG 3000
VISHEVYQQL QRGERSVREV AEADEVRQAL RGTSVIAGVW LEEAGQKLSI YEALRRDLLQ 3060
PEVAVALLEA QAGTGHIIDP ATSARLTVDE AVRAGLVGPE MHEKLLSAEK AVTGYRDPYS 3120
GQSVSLFQAL KKGLIPREQG LRLLDAQLST GGIVDPSKSH RVPLDVAYAR GYLDKETNRA 3180
LTSPRDDARV YLDPSTREPV TYSQLQQRCR SDQLTGLSLL PLSEKAVRAR QEEVYSELQA 3240
RETLEKAKVE VPVGGFKGRA LTVWELISSE YFTEEQRQEL LRQFRTGKVT VEKVIKILIT 3300
IVEEVETQRQ ERLSFSGLRA PVPASELLAS KILSRTQFEQ LKDGKTSVKD LSEVGSVRTL 3360
LQGSGCLAGI YLEDSKEKVT IYEAMRRGLL RPSTATLLLE AQAATGFLVD PVRNQRLYVH 3420
EAVKAGVVGP ELHEKLLSAE KAVTGYKDPY SGSTISLFQA MKKGLVLRDH AIRLLEAQIA 3480
TGGIIDPVHS HRLPVDVAYQ RGYFDEEMNR VLADPSDDTK GFFDPNTHEN LTYLQLLERC 3540
VEDPETGLRL LPLRGAEKTE VVETTQVYTE EETRRAFEET QIDIPGGGSH GGSSMSLWEV 3600
MQSDMIPEDQ RARLMADFQA GRVTKERMII IIIEIIEKTE IIRQQNLASY DYVRRRLTAE 3660
DLYEARIISL ETYNLFREGT KSLREVLEME SAWRYLYGTG SVAGVYLPGS RQTLTIYQAL 3720
KKGLLSAEVA RLLLEAQAAT GFLLDPVKGE RLTVDEAVRK GLVGPELHDR LLSAERAVTG 3780
YRDPYTEQPI SLFQAMKKEL IPAEEALRLL DAQLATGGIV DPRLGFHLPL EVAYQRGYLN 3840
KDTHDQLSEP SEVRSYVDPS TDERLSYTQL LKRCRRDDNS GQMLLPLSDA RKLTFRGLRK 3900
QITVEELVRS QVMDEATALQ LQEGLTSIEE VTKNLQKFLE GTSCIAGVFV DATKERLSVY 3960
QAMKKGIIRP GTAFELLEAQ AATGYVIDPI KGLKLTVEEA VRMGIVGPEF KDKLLSAERA 4020
VTGYKDPYSG KLISLFQAMK KGLILKDHGI RLLEAQIATG GIIDPEESHR LPVEVAYKRG 4080
LFDEEMNEIL TDPSDDTKGF FDPNTEENLT YLQLMERCIT DPQTGLCLLP LKEKKRERKT 4140
SSKSSVRKRR VVIVDPETGK EMSVYEAYRK GLIDHQTYLE LSEQECEWEE ITISSSDGVV 4200
KSMIIDRRSG RQYDIDDAIT KNLIDRSALD QYRAGTLSIT EFADMLSGNA GGFRSRSSSV 4260
GSSSSYPISS AVPRTQLASW SDPTEETGPV AGILDTETLE KVSITEAMHR NLVDNITGQR 4320
LLEAQACTGG IIDPSTGERF PVTEAVNKGL VDKIMVDRIN LAQKAFCGFE DPRTKTKMSA 4380
AQALKKGWLY YEAGQRFLEV QYLTGGLIEP DTPGRVSLDE ALQRGTVDAR TAQKLRDVSA 4440
YSKYLTCPKT KLKISYKDAL DRSMVEEGTG LRLLEAAAQS SKGYYSPYSV SGSGSTAGSR 4500
TGSRTGSRAG SRRGSFDATG SGFSMTFSSS SYSSSGYGRR YASGPSASLG GPESAVA 4557 
Gene Ontology
 GO:0043292; C:contractile fiber; IEA:Compara.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0030056; C:hemidesmosome; IEA:Compara.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0031581; P:hemidesmosome assembly; IEA:Compara. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00307; CH
 PF00681; Plectin 
SMART
 SM00033; CH
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH 
PRINTS