UniProt Accession

 NHP2_DROME; Q9V3U2; Q494M4 

Genbank Protein ID

 AE014296; AF217228; BT023752 

Genbank Nucleotide ID

 AAF49701.1; AAF27630.1; AAZ41760.1 

Protein Name

 H/ACA ribonucleoprotein complex subunit 2-like protein 

Protein Synonyms/Alias

 H/ACA snoRNP protein NHP2; Nucleolar protein family A member 2-like protein 

Gene Name

 NHP2 

Gene Synonyms/Alias

 CG5258 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
3	*****MGKVKVERSE	acetylation	[1]
5	***MGKVKVERSEDA	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs (By similarity). 

Sequence Annotation

 MOD_RES 15 15 Phosphoserine.
 MOD_RES 23 23 Phosphothreonine.  

Keyword

 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005732; C:small nucleolar ribonucleoprotein complex; ISS:UniProtKB.
 GO:0030515; F:snoRNA binding; ISS:UniProtKB.
 GO:0031118; P:rRNA pseudouridine synthesis; ISS:UniProtKB. 

Interpro

 IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
 IPR018492; Ribosomal_L7Ae/L8/Nhp2. 

Pfam

 PF01248; Ribosomal_L7Ae 

SMART

  

PROSITE

 PS01082; RIBOSOMAL_L7AE 

PRINTS

 PR00881; L7ARS6FAMILY.