CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031198
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein phosphatase non-receptor type 
Protein Synonyms/Alias
  
Gene Name
 PTPN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
166LLLMDKRKDPSSVDIubiquitination[1]
175PSSVDIKKVLLEMRKubiquitination[1]
277DCPIKEEKGSPLNAAubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protein phosphatase; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MEEAQRSYIL TQGPLPNTCG HFWEMVWEQK SRGVVMLNRV MEKGSLKCAQ YWPQKEEKEM 60
IFEDTNLKLT LISEDIKSYY TVRQLELENL TTQETREILH FHYTTWPDFG VPESPASFLN 120
FLFKVRESGS LSPEHGPVVV HCSAGIGRSG TFCLADTCLL LMDKRKDPSS VDIKKVLLEM 180
RKFRMGLIQT ADQLRFSYLA VIEGAKFIMG DSSVQDQWKE LSHEDLEPPP EHIPPPPRPP 240
KRILEPHNGK CREFFPNHQW VKEETQEDKD CPIKEEKGSP LNAAPYGIES MSQDTEVRSR 300
VVGGSLRGAQ AASPAKGEPS LPEKDEDHAL SYWKPFLVNM CVATVLTAGA YLCYRFLFNS 360
NT 362 
Gene Ontology
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0008286; P:insulin receptor signaling pathway; IEA:Compara.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
 GO:0046626; P:regulation of insulin receptor signaling pathway; IEA:Compara. 
Interpro
 IPR012265; Ptpn1/Ptpn2.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00102; Y_phosphatase 
SMART
 SM00194; PTPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.