CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015557
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family member 9 
Protein Synonyms/Alias
 TBC1 domain family member 9A 
Gene Name
 TBC1D9 
Gene Synonyms/Alias
 KIAA0882; TBC1D9A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
552LVEKSMGKYNLATEEubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May act as a GTPase-activating protein for Rab family protein(s). 
Sequence Annotation
 DOMAIN 146 213 GRAM 1.
 DOMAIN 293 361 GRAM 2.
 DOMAIN 515 702 Rab-GAP TBC.
 DOMAIN 886 921 EF-hand.  
Keyword
 Complete proteome; GTPase activation; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1266 AA 
Protein Sequence
MWVNPEEVLL ANALWITERA NPYFILQRRK GHAGDGGGGG GLAGLLVGTL DVVLDSSARV 60
APYRILYQTP DSLVYWTIAC GGSRKEITEH WEWLEQNLLQ TLSIFENEND ITTFVRGKIQ 120
GIIAEYNKIN DVKEDDDTEK FKEAIVKFHR LFGMPEEEKL VNYYSCSYWK GKVPRQGWMY 180
LSINHLCFYS FLMGREAKLV IRWVDITQLE KNATLLLPDV IKVSTRSSEH FFSVFLNINE 240
TFKLMEQLAN IAMRQLLDNE GFEQDRSLPK LKRKSPKKVS ALKRDLDARA KSERYRALFR 300
LPKDEKLDGH TDCTLWTPFN KMHILGQMFV STNYICFTSK EENLCSLIIP LREVTIVEKA 360
DSSSVLPSPL SISTRNRMTF LFANLKDRDF LVQRISDFLQ QTTSKIYSDK EFAGSYNSSD 420
DEVYSRPSSL VSSSPQRSTS SDADGERQFN LNGNSVPTAT QTLMTMYRRR SPEEFNPKLA 480
KEFLKEQAWK IHFAEYGQGI CMYRTEKTRE LVLKGIPESM RGELWLLLSG AINEKATHPG 540
YYEDLVEKSM GKYNLATEEI ERDLHRSLPE HPAFQNEMGI AALRRVLTAY AFRNPNIGYC 600
QAMNIVTSVL LLYAKEEEAF WLLVALCERM LPDYYNTRVV GALVDQGVFE ELARDYVPQL 660
YDCMQDLGVI STISLSWFLT LFLSVMPFES AVVVVDCFFY EGIKVIFQLA LAVLDANVDK 720
LLNCKDDGEA MTVLGRYLDS VTNKDSTLPP IPHLHSLLSD DVEPYPEVDI FRLIRTSYEK 780
FGTIRADLIE QMRFKQRLKV IQTLEDTTKR NVVRTIVTET SFTIDELEEL YALFKAEHLT 840
SCYWGGSSNA LDRHDPSLPY LEQYRIDFEQ FKGMFALLFP WACGTHSDVL ASRLFQLLDE 900
NGDSLINFRE FVSGLSAACH GDLTEKLKLL YKMHVLPEPS SDQDEPDSAF EATQYFFEDI 960
TPECTHVVGL DSRSKQGADD GFVTVSLKPD KGKRANSQEN RNYLRLWTPE NKSKSKNAKD 1020
LPKLNQGQFI ELCKTMYNMF SEDPNEQELY HATAAVTSLL LEIGEVGKLF VAQPAKEGGS 1080
GGSGPSCHQG IPGVLFPKKG PGQPYVVESV EPLPASLAPD SEEHSLGGQM EDIKLEDSSP 1140
RDNGACSSML ISDDDTKDDS SMSSYSVLSA GSHEEDKLHC EDIGEDTVLV RSGQGTAALP 1200
RSTSLDRDWA ITFEQFLASL LTEPALVKYF DKPVCMMARI TSAKNIRMMG KPLTSASDYE 1260
ISAMSG 1266 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR004182; GRAM.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF02893; GRAM
 PF00566; RabGAP-TBC 
SMART
 SM00568; GRAM
 SM00164; TBC 
PROSITE
 PS50222; EF_HAND_2
 PS50086; TBC_RABGAP 
PRINTS