CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015546
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM83H 
Protein Synonyms/Alias
  
Gene Name
 FAM83H 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
324PTPFSFPKRAHLLFPubiquitination[1]
408HLEMDAFKRHSFATEubiquitination[2]
475RPQGLFEKLRGGRAGubiquitination[1, 2]
639VPAAFPTKVPVPGPGubiquitination[2]
664PEEPGLAKQDSFRSRubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May play a major role in the structural organization and calcification of developing enamel. 
Sequence Annotation
 MOD_RES 465 465 Phosphothreonine.
 MOD_RES 516 516 Phosphoserine (By similarity).
 MOD_RES 523 523 Phosphoserine.
 MOD_RES 647 647 Phosphoserine.
 MOD_RES 759 759 Phosphoserine.
 MOD_RES 785 785 Phosphoserine.
 MOD_RES 850 850 Phosphoserine (By similarity).
 MOD_RES 870 870 Phosphoserine.
 MOD_RES 881 881 Phosphoserine.
 MOD_RES 883 883 Phosphothreonine.
 MOD_RES 892 892 Phosphoserine.
 MOD_RES 903 903 Phosphoserine.
 MOD_RES 914 914 Phosphoserine.
 MOD_RES 925 925 Phosphoserine (By similarity).
 MOD_RES 936 936 Phosphoserine.
 MOD_RES 945 945 Phosphoserine.
 MOD_RES 1003 1003 Phosphoserine.
 MOD_RES 1009 1009 Phosphoserine (By similarity).
 MOD_RES 1024 1024 Phosphoserine.
 MOD_RES 1025 1025 Phosphoserine.
 MOD_RES 1040 1040 Phosphothreonine.
 MOD_RES 1048 1048 Phosphoserine.  
Keyword
 Amelogenesis imperfecta; Biomineralization; Complete proteome; Disease mutation; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1179 AA 
Protein Sequence
MARRSQSSSQ GDNPLAPGYL PPHYKEYYRL AVDALAEGGS EAYSRFLATE GAPDFLCPEE 60
LEHVSRHLRP PQYVTREPPE GSLLDVDMDG SSGTYWPVNS DQAVPELDLG WPLTFGFQGT 120
EVTTLVQPPP PDSPSIKDEA RRMIRSAQQV VAVVMDMFTD VDLLSEVLEA AARRVPVYIL 180
LDEMNAQHFL DMADKCRVNL QHVDFLRVRT VAGPTYYCRT GKSFKGHVKE KFLLVDCAVV 240
MSGSYSFMWS FEKIHRSLAH VFQGELVSSF DEEFRILFAQ SEPLVPSAAA LARMDAYALA 300
PYAGAGPLVG VPGVGAPTPF SFPKRAHLLF PPPREEGLGF PSFLDPDRHF LSAFRREEPP 360
RMPGGALEPH AGLRPLSRRL EAEAGPAGEL AGARGFFQAR HLEMDAFKRH SFATEGAGAV 420
ENFAAARQVS RQTFLSHGDD FRFQTSHFHR DQLYQQQYQW DPQLTPARPQ GLFEKLRGGR 480
AGFADPDDFT LGAGPRFPEL GPDGHQRLDY VPSSASREVR HGSDPAFAPG PRGLEPSGAP 540
RPNLTQRFPC QAAARPGPDP APEAEPERRG GPEGRAGLRR WRLASYLSGC HGEDGGDDGL 600
PAPMEAEAYE DDVLAPGGRA PAGDLLPSAF RVPAAFPTKV PVPGPGSGGN GPEREGPEEP 660
GLAKQDSFRS RLNPLVQRSS RLRSSLIFST SQAEGAAGAA AATEKVQLLH KEQTVSETLG 720
PGGEAVRSAA STKVAELLEK YKGPARDPGG GAGAITVASH SKAVVSQAWR EEVAAPGAVG 780
GERRSLESCL LDLRDSFAQQ LHQEAERQPG AASLTAAQLL DTLGRSGSDR LPSRFLSAQS 840
HSTSPQGLDS PLPLEGSGAH QVLHNESKGS PTSAYPERKG SPTPGFSTRR GSPTTGFIEQ 900
KGSPTSAYPE RRGSPVPPVP ERRSSPVPPV PERRGSLTLT ISGESPKAGP AEEGPSGPME 960
VLRKGSLRLR QLLSPKGERR MEDEGGFPVP QENGQPESPR RLSLGQGDST EAATEERGPR 1020
ARLSSATANA LYSSNLRDDT KAILEQISAH GQKHRAVPAP SPGPTHNSPE LGRPPAAGVL 1080
APDMSDKDKC SAIFRSDSLG TQGRLSRTLP ASAEERDRLL RRMESMRKEK RVYSRFEVFC 1140
KKEEASSPGA GEGPAEEGTR DSKVGKFVPK ILGTFKSKK 1179 
Gene Ontology
 GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW. 
Interpro
 IPR012461; DUF1669. 
Pfam
 PF07894; DUF1669 
SMART
  
PROSITE
  
PRINTS