| Tag | Content |
|---|
| CPLM ID | CPLM-018615 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Trimethyllysine dioxygenase, mitochondrial |
Protein Synonyms/Alias | Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TML dioxygenase; TMLD |
Gene Name | Tmlhe |
Gene Synonyms/Alias | Tmlh |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 142 | KNSYEGQKQEVIQPR | acetylation | [1] | | 174 | FQGFLETKEGLKKFL | acetylation | [1] | | 236 | RGDTAYTKLALDRHT | acetylation | [1] | | 378 | WVKLKPGKVLFIDNW | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). |
Sequence Annotation | METAL 242 242 Iron; catalytic (By similarity).
METAL 244 244 Iron; catalytic (By similarity).
METAL 389 389 Iron; catalytic (By similarity).
MOD_RES 236 236 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Alternative splicing; Carnitine biosynthesis; Complete proteome; Dioxygenase; Direct protein sequencing; Iron; Metal-binding; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 421 AA |
Protein Sequence | MWYHKLLHQQ SRLQNLMKRG DIAHGLRLSG FKSLFPFSLH WCHTASKSVN CTWHQHEDHL 60
ELQYASTVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIKPKTIR LDESTLFFTW 120
PDGHVTRYDL DWLVKNSYEG QKQEVIQPRV LWNAKLYQDA QLPSVDFQGF LETKEGLKKF 180
LQNFLLYGIA FVENVPPTQE HTEKLARRVS LIRETIYGRM WYFTSDFSRG DTAYTKLALD 240
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAQQ VLQRAPEEFD LLSQVPLKHE 300
YIENVGQCHN HMIGVGPILN IYPWNKELYL IRYNNYDRAV INTVPYDVVR RWYAAHRTLT 360
TELRRPENEL WVKLKPGKVL FIDNWRVLHG RESFTGYRQL CGCYLTRDDV LNTARILGLH 420
A 421 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:RGD. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0031418; F:L-ascorbic acid binding; IEA:InterPro. GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. GO:0050353; F:trimethyllysine dioxygenase activity; IDA:RGD. GO:0045329; P:carnitine biosynthetic process; TAS:RGD. GO:0051354; P:negative regulation of oxidoreductase activity; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |