UniProt Accession

 CNR1_RAT; P20272 

Genbank Protein ID

 X55812; U40395 

Genbank Nucleotide ID

 CAA39332.1; AAA99067.1 

Protein Name

 Cannabinoid receptor 1 

Protein Synonyms/Alias

 CB-R; CB1; Brain-type cannabinoid receptor 

Gene Name

 Cnr1 

Gene Synonyms/Alias

 Skr6 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
316	MIQRGTQKSIIIHTS	ubiquitination	[1]
452	RAAESCIKSTVKIAK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. 

Sequence Annotation

 LIPID 416 416 S-palmitoyl cysteine.
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 84 84 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 473 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004949; F:cannabinoid receptor activity; IMP:RGD.
 GO:0008144; F:drug binding; IMP:RGD.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
 GO:0007568; P:aging; IMP:RGD.
 GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
 GO:0007613; P:memory; IDA:RGD.
 GO:0045759; P:negative regulation of action potential; IMP:RGD.
 GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
 GO:0033602; P:negative regulation of dopamine secretion; IMP:RGD.
 GO:0031999; P:negative regulation of fatty acid beta-oxidation; IMP:RGD.
 GO:0033004; P:negative regulation of mast cell activation; IDA:RGD.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IMP:RGD.
 GO:0002866; P:positive regulation of acute inflammatory response to antigenic stimulus; IMP:RGD.
 GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
 GO:0045777; P:positive regulation of blood pressure; IMP:RGD.
 GO:0031622; P:positive regulation of fever generation; IMP:RGD.
 GO:0010976; P:positive regulation of neuron projection development; IDA:RGD.
 GO:0060259; P:regulation of feeding behavior; IMP:RGD.
 GO:0050796; P:regulation of insulin secretion; IMP:RGD.
 GO:0060405; P:regulation of penile erection; IMP:RGD.
 GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:RGD.
 GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:RGD.
 GO:0042220; P:response to cocaine; IMP:RGD.
 GO:0045471; P:response to ethanol; IMP:RGD.
 GO:0032496; P:response to lipopolysaccharide; IMP:RGD.
 GO:0043278; P:response to morphine; IMP:RGD.
 GO:0035094; P:response to nicotine; IMP:RGD.
 GO:0007584; P:response to nutrient; IEP:RGD.
 GO:0019233; P:sensory perception of pain; IMP:RGD.
 GO:0007283; P:spermatogenesis; IEP:RGD. 

Interpro

 IPR002230; Cnbnoid_rcpt.
 IPR000810; Cnoid_rcpt_1.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00522; CANABINOID1R.
 PR00362; CANNABINOIDR.
 PR00237; GPCRRHODOPSN.