UniProt Accession

 XPP3_MOUSE; B7ZMP1; Q8BHT9 

Genbank Protein ID

 AK088324; CH466550; CH466550; BC137569; BC144717 

Genbank Nucleotide ID

 BAC40282.1; EDL04573.1; EDL04574.1; AAI37570.1; AAI44718.1 

Protein Name

 Probable Xaa-Pro aminopeptidase 3 

Protein Synonyms/Alias

 X-Pro aminopeptidase 3; Aminopeptidase P3; APP3 

Gene Name

 Xpnpep3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
406	LGITKTSKESAFKAA	acetylation	[1]
411	TSKESAFKAARKYCP	acetylation	[1, 2]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

  

Sequence Annotation

 METAL 331 331 Manganese 2 (By similarity).
 METAL 342 342 Manganese 1 (By similarity).
 METAL 342 342 Manganese 2 (By similarity).
 METAL 423 423 Manganese 1 (By similarity).
 METAL 450 450 Manganese 1 (By similarity).
 METAL 474 474 Manganese 1 (By similarity).
 METAL 474 474 Manganese 2 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Manganese; Metal-binding; Mitochondrion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 506 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004177; F:aminopeptidase activity; IEA:InterPro.
 GO:0030145; F:manganese ion binding; IEA:InterPro.
 GO:0009987; P:cellular process; IEA:InterPro.
 GO:0003094; P:glomerular filtration; IEA:Compara.
 GO:0016485; P:protein processing; IEA:Compara. 

Interpro

 IPR007865; Aminopep_P_N.
 IPR000994; Pept_M24_structural-domain. 

Pfam

 PF05195; AMP_N
 PF00557; Peptidase_M24 

SMART

 SM01011; AMP_N 

PROSITE

  

PRINTS