UniProt Accession

 PHC2_HUMAN; Q8IXK0; A1L4Q1; D3DPR2; Q2TAL3; Q5T0C1; Q6NUJ6; Q6ZQR1; Q8N306; Q8TAG8; Q96BL4; Q9Y4Y7 

Genbank Protein ID

 AJ419231; AK128821; AL513327; AL513327; AL513327; CH471059; CH471059; BC015450; BC028396; BC029269; BC068573; BC092492; BC110863; BC130630; AJ242730 

Genbank Nucleotide ID

 CAD11673.1; BAC87622.1; CAI13955.1; CAI13956.1; CAI13957.1; EAX07457.1; EAX07459.1; AAH15450.1; AAH28396.3; AAH29269.1; AAH68573.1; AAH92492.1; AAI10864.2; AAI30631.1; CAB44779.1 

Protein Name

 Polyhomeotic-like protein 2 

Protein Synonyms/Alias

 hPH2; Early development regulatory protein 2 

Gene Name

 PHC2 

Gene Synonyms/Alias

 EDR2; PH2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
97	EPYLQESKEEGAPLK	ubiquitination	[1]
258	FLPSEPTKWNVEDVY	ubiquitination	[1]
295	GQALLLLKEDHLMSA	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 

Sequence Annotation

 DOMAIN 794 858 SAM.
 ZN_FING 633 667 FCS-type.
 MOTIF 558 587 HD1.
 MOD_RES 621 621 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 858 AA 

Protein Sequence

Gene Ontology

 GO:0035102; C:PRC1 complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR001660; SAM.
 IPR013761; SAM/pointed.
 IPR021129; SAM_type1.
 IPR012313; Znf_FCS. 

Pfam

 PF00536; SAM_1 

SMART

 SM00454; SAM 

PROSITE

 PS50105; SAM_DOMAIN
 PS51024; ZF_FCS 

PRINTS