UniProt Accession

 PTGR1_MOUSE; Q91YR9; Q3TKT6; Q9CPS1 

Genbank Protein ID

 AK010888; AK011962; AK035425; AK134440; AK166835; BC014865 

Genbank Nucleotide ID

 BAB27248.1; BAB27941.1; BAC29060.1; BAE22145.1; BAE39057.1; AAH14865.1 

Protein Name

 Prostaglandin reductase 1 

Protein Synonyms/Alias

 PRG-1; 15-oxoprostaglandin 13-reductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase 

Gene Name

 Ptgr1 

Gene Synonyms/Alias

 Ltb4dh 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
178	GTAGSDEKVAYLKKL	acetylation	[1, 2]
184	EKVAYLKKLGFDVAF	acetylation	[3]
197	AFNYKTVKSLEEALR	acetylation	[2]
318	AAFMGMLKGENLGKT	acetylation	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12- oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity). 

Sequence Annotation

 NP_BIND 152 155 NADP (By similarity).
 NP_BIND 239 245 NADP (By similarity).
 NP_BIND 270 272 NADP (By similarity).
 BINDING 178 178 NADP (By similarity).
 BINDING 193 193 NADP (By similarity).
 BINDING 217 217 NADP (By similarity).
 BINDING 321 321 NADP (By similarity).  

Keyword

 Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0036132; F:13-prostaglandin reductase activity; IEA:EC.
 GO:0047522; F:15-oxoprostaglandin 13-oxidase activity; IEA:EC.
 GO:0032440; F:2-alkenal reductase [NAD(P)] activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006693; P:prostaglandin metabolic process; IEA:GOC.
 GO:0009636; P:response to toxic substance; IEA:Compara. 

Interpro

 IPR013149; ADH_C.
 IPR002085; ADH_SF_Zn-type.
 IPR014190; B4_12hDH.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00107; ADH_zinc_N 

SMART

  

PROSITE

  

PRINTS