| Tag | Content |
|---|
| CPLM ID | CPLM-016820 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | REST corepressor 1 |
Protein Synonyms/Alias | Protein CoREST |
Gene Name | Rcor1 |
Gene Synonyms/Alias | D12Wsu95e; Kiaa0071 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 148 | DEYIAIAKEKHGYNM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
Sequence Annotation | DOMAIN 94 180 ELM2.
DOMAIN 181 232 SANT 1.
DOMAIN 372 423 SANT 2.
REGION 69 248 Interaction with HDAC1 (By similarity).
REGION 287 375 Interaction with KDM1A (By similarity).
MOD_RES 118 118 Phosphoserine (By similarity).
MOD_RES 251 251 Phosphoserine.
MOD_RES 258 258 Phosphothreonine.
MOD_RES 451 451 Phosphoserine (By similarity). |
Keyword | Chromatin regulator; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 477 AA |
Protein Sequence | MVEKGPEVSG KRRGRNTAAS AASAAASAAS AAASAAASAG TXSASAAAAA SAAAXPNNGQ 60
NKSLAAAAPN GNSGSNSWEE GSSGSSSDEE HGGGGMRVGP QYQAAVPDFD PAKLARRSQE 120
RDNLGMLVWS PNQSLSEAKL DEYIAIAKEK HGYNMEQALG MLFWHKHNIE KSLADLPNFT 180
PFPDEWTVED KVLFEQAFSF HGKTFHRIQQ MLPDKSIASL VKFYYSWKKT RTKTSVMDRH 240
ARKQKREREE SEDELEETNG SNPVDIEIDP NKESKKEVPP TETVPQVKKE KHSTQAKNRA 300
KRKPPKGMFL SQEDVEAVSA NATAATTVLR QLDMELVSIK RQIQNIKQTN SALKEKLDGG 360
IEPYRLPEVI QKCNARWTTE EQLLAVQAIR KYGRDFQAIS DVIGNKSVVQ VKNFFVNYRR 420
RFNIDEVLQE WEAEHGKDET NGPANQKPVK SPESSIKIPE EEDEAASVLD VRYASAS 477 |
Gene Ontology | GO:0017053; C:transcriptional repressor complex; IEA:Compara. GO:0003682; F:chromatin binding; IEA:InterPro. GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara. GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara. GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB. GO:0070933; P:histone H4 deacetylation; IEA:Compara. GO:0045654; P:positive regulation of megakaryocyte differentiation; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |