CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000052
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tubby-related protein 1 
Protein Synonyms/Alias
 Tubby-like protein 1 
Gene Name
 TULP1 
Gene Synonyms/Alias
 TUBL1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
207EEAATVIKKSNQKGKacetylation[1]
220GKAKGKGKKKAKEERacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. 
Sequence Annotation
  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Disease mutation; Leber congenital amaurosis; Membrane; Phagocytosis; Polymorphism; Reference proteome; Retinitis pigmentosa; Secreted; Sensory transduction; Synapse; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 542 AA 
Protein Sequence
MPLRDETLRE VWASDSGHEE ESLSPEAPRR PKQRPAPAQR LRKKRTEAPE SPCPTGSKPR 60
KPGEEEEEEE DEEDEEEEAE EKKEKILLPP KKPLREKSSA DLKERRAKAQ GPRGDLGSPD 120
PPPKPLRVRN KEAPAGEGTK MRKTKKKGSG EADKDPSGSP ASARKSPAAM FLVGEGSPDK 180
KALKKKGTPK GARKEEEEEE EAATVIKKSN QKGKAKGKGK KKAKEERAPS PPVEVDEPRE 240
FVLRPAPQGR TVRCRLTRDK KGMDRGMYPS YFLHLDTEKK VFLLAGRKRK RSKTANYLIS 300
IDPTNLSRGG ENFIGKLRSN LLGNRFTVFD NGQNPQRGYS TNVASLRQEL AAVIYETNVL 360
GFRGPRRMTV IIPGMSAENE RVPIRPRNAS DGLLVRWQNK TLESLIELHN KPPVWNDDSG 420
SYTLNFQGRV TQASVKNFQI VHADDPDYIV LQFGRVAEDA FTLDYRYPLC ALQAFAIALS 480
SFDGKLACE 489 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0001917; C:photoreceptor inner segment; ISS:UniProtKB.
 GO:0001750; C:photoreceptor outer segment; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0045202; C:synapse; ISS:UniProtKB.
 GO:0051015; F:actin filament binding; IDA:UniProtKB.
 GO:0008020; F:G-protein coupled photoreceptor activity; IEA:Compara.
 GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:UniProtKB.
 GO:0016358; P:dendrite development; ISS:UniProtKB.
 GO:0042462; P:eye photoreceptor cell development; ISS:UniProtKB.
 GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
 GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
 GO:0007602; P:phototransduction; IEA:Compara.
 GO:0050766; P:positive regulation of phagocytosis; IDA:UniProtKB.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara. 
Interpro
 IPR000007; Tubby_C.
 IPR025659; Tubby_C-like.
 IPR018066; Tubby_C_CS. 
Pfam
 PF01167; Tub 
SMART
  
PROSITE
 PS01200; TUB_1
 PS01201; TUB_2 
PRINTS
 PR01573; SUPERTUBBY.