CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033882
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA ligase 
Protein Synonyms/Alias
  
Gene Name
 Lig1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
29MSFFQPTKEGKAKKPacetylation[1]
160LEEQNEDKTKTAKKRacetylation[2, 3]
224PVCKAGVKLKPQEEEacetylation[1]
241KPPARGAKTLSSFFTacetylation[1, 3]
255TPRKPAVKTEVKQEEacetylation[1]
582VDFTCEYKYDGQRAQacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 687 AA 
Protein Sequence
MRKKEQERKG ETSAANMQRS IMSFFQPTKE GKAKKPEKET PSSIREKEPP PKVALKERNQ 60
VVPESDSPVK RTGRKVAQVL SCEGEDEDEA PGTPKVQKPV SDSEQSSPPS PDTCPENSPV 120
FNCSSPMDIS PSGFPKRRTA RKQLPKRTIQ DTLEEQNEDK TKTAKKRKKE EETPKESLAE 180
AEDVKQKEEK EGDQLIVPSE PTKSPESVTL TKTENIPVCK AGVKLKPQEE EQSKPPARGA 240
KTLSSFFTPR KPAVKTEVKQ EESGTLRKEE TKGTLDPANY NPSKNNYHPI EDACWKHGQK 300
VPFLAVARTF EKIEEVSARL KMVETLSNLL RSVVALSPPD LLPVLYLSLN RLGPPQQGLE 360
LGVGDGVLLK AVAQATGRQL ESIRAEVAEK GDVGLVAENS RSTQRLMLPP PPLTISGVFT 420
KFCDIARLTG SASMAKKMDI IKGLFVACRH SEARYIARSL SGRLRLGLAE QSVLAALAQA 480
VSLTPPGQEF PTAVVDAGKG KTAEARKMWL EEQGMILKQT FCEVPDLDRI IPVLLEHGLE 540
RLPEHCKLSP GVPLKPMLAH PTRGVSEVLK RFEEVDFTCE YKYDGQRAQI HVLEGGEVKI 600
FSRNQEDNTG KYPDIISRIP KIKHPSVTSF ILDTEAVAWD REKKQIQPFQ VLTTRKRKEV 660
DASEIQVQVC LYAFDLIYLN GESLVRQ 687 
Gene Ontology
 GO:0005694; C:chromosome; IBA:RefGenome.
 GO:0005739; C:mitochondrion; IBA:RefGenome.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003910; F:DNA ligase (ATP) activity; IBA:RefGenome.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:MGI.
 GO:0006273; P:lagging strand elongation; IBA:RefGenome.
 GO:0042542; P:response to hydrogen peroxide; IMP:MGI. 
Interpro
 IPR000977; DNA_ligase_ATP-dep.
 IPR012310; DNA_ligase_ATP-dep_cent.
 IPR016059; DNA_ligase_ATP-dep_CS.
 IPR012308; DNA_ligase_ATP-dep_N. 
Pfam
 PF01068; DNA_ligase_A_M
 PF04675; DNA_ligase_A_N 
SMART
  
PROSITE
 PS00697; DNA_LIGASE_A1
 PS50160; DNA_LIGASE_A3 
PRINTS