UniProt Accession

 DBLOH_HUMAN; Q9NR28; B2RDQ0; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6 

Genbank Protein ID

 AF262240; AY313210; AK024768; AK057778; AK315629; AF298770; AC048338; BC004417; BC011909 

Genbank Nucleotide ID

 AAF87716.1; AAQ86939.1; BAB14994.1; BAB71568.1; BAG37997.1; AAG22077.1; AAH04417.1; AAH11909.1 

Protein Name

 Diablo homolog, mitochondrial 

Protein Synonyms/Alias

 Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac 

Gene Name

 DIABLO 

Gene Synonyms/Alias

 SMAC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	QYTSLLGKMNSEEED	ubiquitination	[1]
93	ARAEMTSKHQEYLKL	ubiquitination	[1]
138	RNHIQLVKLQVEEVH	ubiquitination	[1]
166	QIEELRQKTQEEGEE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. 

Sequence Annotation

 MOTIF 56 60 IAP-binding.  

Keyword

 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Deafness; Direct protein sequencing; Disease mutation; Mitochondrion; Non-syndromic deafness; Reference proteome; Transit peptide; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL.
 GO:0005758; C:mitochondrial intermembrane space; TAS:Reactome.
 GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; TAS:ProtInc.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; TAS:ProtInc.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:UniProtKB.
 GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; IEA:Compara. 

Interpro

 IPR015142; Smac_DIABLO.
 IPR009062; Smac_DIABLO-like. 

Pfam

 PF09057; Smac_DIABLO 

SMART

  

PROSITE

  

PRINTS