UniProt Accession

 RL19_ECOLI; P0A7K6; P02420 

Genbank Protein ID

 X01818; U00096; AP009048 

Genbank Nucleotide ID

 CAA25960.1; AAC75655.1; BAA16491.1 

Protein Name

 50S ribosomal protein L19 

Protein Synonyms/Alias

  

Gene Name

 rplS 

Gene Synonyms/Alias

 b2606; JW2587 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
6	**MSNIIKQLEQEQM	acetylation	[1, 2]
14	QLEQEQMKQDVPSFR	acetylation	[2]
37	VWVVEGSKKRLQAFE	acetylation	[2]
38	WVVEGSKKRLQAFEG	acetylation	[2]
87	VVDSISVKRRGAVRK	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 This protein is located at the 30S-50S ribosomal subunit interface. In the 70S ribosome (PubMed:12809609) it has been modeled to make two contacts with the 16S rRNA of the 30S subunit forming part of bridges B6 and B8. In the 3.5 A resolved structures (PubMed:16272117) L14 and L19 interact and together make contact with the 16S rRNA. The protein conformation is quite different between the 50S and 70S structures, which may be necessary for translocation. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 115 AA 

Protein Sequence

Gene Ontology

 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR001857; Ribosomal_L19.
 IPR018257; Ribosomal_L19_CS.
 IPR008991; Translation_prot_SH3-like. 

Pfam

 PF01245; Ribosomal_L19 

SMART

  

PROSITE

 PS01015; RIBOSOMAL_L19 

PRINTS

 PR00061; RIBOSOMALL19.