CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027138
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MKIAA0968 protein 
Protein Synonyms/Alias
  
Gene Name
 Camk2a 
Gene Synonyms/Alias
 mKIAA0968 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
30QLFEELGKGAFSVVRubiquitination[1]
41SVVRRCVKVLAGQEYubiquitination[1]
51AGQEYAAKIINTKKLubiquitination[1]
56AAKIINTKKLSARDHubiquitination[1]
57AKIINTKKLSARDHQubiquitination[1]
77ARICRLLKHPNIVRLubiquitination[1]
146GVVHRDLKPENLLLAubiquitination[1]
155ENLLLASKLKGAAVKubiquitination[1]
157LLLASKLKGAAVKLAubiquitination[1]
235HRLYQQIKAGAYDFPubiquitination[1]
254DTVTPEAKDLINKMLubiquitination[1]
259EAKDLINKMLTINPSubiquitination[1]
267MLTINPSKRITAAEAubiquitination[1]
276ITAAEALKHPWISHRubiquitination[1]
300QETVDCLKKFNARRKubiquitination[1]
309FNARRKLKGAILTTMubiquitination[1]
337NKKNDGVKESSESTNubiquitination[1]
353TIEDEDTKVRKQEIIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 487 AA 
Protein Sequence
SLACLPSARM ATITCTRFTE EYQLFEELGK GAFSVVRRCV KVLAGQEYAA KIINTKKLSA 60
RDHQKLEREA RICRLLKHPN IVRLHDSISE EGHHYLIFDL VTGGELFEDI VAREYYSEAD 120
ASHCIQQILE AVLHCHQMGV VHRDLKPENL LLASKLKGAA VKLADFGLAI EVEGEQQAWF 180
GFAGTPGYLS PEVLRKDPYG KPVDLWACGV ILYILLVGYP PFWDEDQHRL YQQIKAGAYD 240
FPSPEWDTVT PEAKDLINKM LTINPSKRIT AAEALKHPWI SHRSTVASCM HRQETVDCLK 300
KFNARRKLKG AILTTMLATR NFSGGKSGGN KKNDGVKESS ESTNTTIEDE DTKVRKQEII 360
KVTEQLIEAI SNGDFESYTK MCDPGMTAFE PEALGNLVEG LDFHRFYFEN LWSRNSKPVH 420
TTILNPHIHL MGDESACIAY IRITQYLDAG GIPRTAQSEE TRVWHRRDGK WQIVHFHRSG 480
APSVLPH 487 
Gene Ontology
 GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IMP:MGI.
 GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:MGI.
 GO:0046928; P:regulation of neurotransmitter secretion; IMP:MGI. 
Interpro
 IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
 IPR013543; Ca/CaM-dep_prot_kinase-assoc.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF08332; CaMKII_AD
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS