CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043304
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 COX4I1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29RAHESVVKSEDFSLPubiquitination[1, 2]
53LPEVAHVKHLSASQKacetylation[3]
53LPEVAHVKHLSASQKubiquitination[1, 2, 4]
60KHLSASQKALKEKEKacetylation[3]
60KHLSASQKALKEKEKubiquitination[2]
67KALKEKEKASWSSLSubiquitination[2]
87ELYRIKFKESFAEMNacetylation[3]
87ELYRIKFKESFAEMNubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 126 AA 
Protein Sequence
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK 60
ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW 120
QKHYGE 126 
Gene Ontology
 GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro. 
Interpro
 IPR013288; Cyt_c_oxidase_su4.
 IPR004203; Cyt_c_oxidase_su4_fam. 
Pfam
 PF02936; COX4 
SMART
  
PROSITE
  
PRINTS
 PR01873; CYTCOXIDASE4.