UniProt Accession

 E7EWH8_HUMAN; E7EWH8 

Genbank Protein ID

 AL583862 

Genbank Nucleotide ID

  

Protein Name

 Hydroxypyruvate isomerase 

Protein Synonyms/Alias

  

Gene Name

 HYI 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
71	TPPGDQEKGEMGLGA	ubiquitination	[1, 2]
122	GADRIAVKAEMEAVF	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Isomerase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 276 AA 

Protein Sequence

Gene Ontology

 GO:0008903; F:hydroxypyruvate isomerase activity; IEA:EC. 

Interpro

 IPR026040; HyI-like.
 IPR013022; Xyl_isomerase-like_TIM-brl. 

Pfam

 PF01261; AP_endonuc_2 

SMART

  

PROSITE

  

PRINTS