| Tag | Content |
|---|
| CPLM ID | CPLM-021860 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CD2-associated protein |
Protein Synonyms/Alias | Mesenchyme-to-epithelium transition protein with SH3 domains 1; METS-1 |
Gene Name | Cd2ap |
Gene Synonyms/Alias | Mets1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 71 | KDDNLPIKRERQGNV | ubiquitination | [1] | | 102 | IQPHPQTKAIKKKTK | ubiquitination | [1] | | 221 | IGFGDIFKEGSVKLR | ubiquitination | [1] | | 457 | EQLPVRPKSVDLDAF | ubiquitination | [1] | | 568 | FLTPLELKAKAEADD | ubiquitination | [1] | | 629 | NLEVEIAKLKKAVLL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for cytokinesis (By similarity). Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen- presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. |
Sequence Annotation | DOMAIN 1 59 SH3 1; truncated.
DOMAIN 108 167 SH3 2.
DOMAIN 269 330 SH3 3.
REGION 1 175 Interaction with ANLN and localization to
MOTIF 336 352 SH3-binding (Potential).
MOTIF 378 397 SH3-binding (Potential).
MOTIF 410 422 SH3-binding (Potential).
MOD_RES 224 224 Phosphoserine (By similarity).
MOD_RES 458 458 Phosphoserine.
MOD_RES 510 510 Phosphoserine (By similarity).
MOD_RES 514 514 Phosphoserine (By similarity). |
Keyword | 3D-structure; Cell cycle; Cell division; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Phosphoprotein; Reference proteome; Repeat; SH3 domain; SH3-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 637 AA |
Protein Sequence | MVDYIVEYDY DAVHDDELTI RVGEIIRNVK KLQEEGWLEG ELNGRRGMFP DNFVKEIKRE 60
TEPKDDNLPI KRERQGNVAS LVQRISTYGL PAGGIQPHPQ TKAIKKKTKK RQCKVLFDYS 120
PQNEDELELI VGDVIDVIEE VEEGWWSGTL NNKLGLFPSN FVKELESTED GETHNAQEES 180
EVPLTGPTSP LPSPGNGSEP APGSVAQPKK IRGIGFGDIF KEGSVKLRTR TSSSETEEKK 240
TEKPLILQPL GSRTQNVEVT KPDVDGKIKA KEYCRTLFPY TGTNEDELTF REGEIIHLIS 300
KETGEAGWWK GELNGKEGVF PDNFAVQISE LDKDFPKPKK PPPPAKGPAP KPDLSAAEKK 360
AFPLKAEEKD EKSLLEQKPS KPAAPQVPPK KPTAPTKASN LLRSPGAVYP KRPEKPVPPP 420
PPAAKINGEV SIISSKIDTE PVSKPKLDPE QLPVRPKSVD LDAFVARNSK ETDDVNFDDI 480
ASSENLLHLT ANRPKMPGRR LPGRFNGGHS PTQSPEKTLK LPKEDDSGNL KPLEFKKDAS 540
YSSKSSLSTP SSASKVNTAA FLTPLELKAK AEADDGKRNS VDELRAQIIE LLCIVDALKK 600
DHGKELEKLR KELEEEKAMR SNLEVEIAKL KKAVLLS 637 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |