UniProt Accession

 MACD1_HUMAN; Q9BQ69; Q9UH96 

Genbank Protein ID

 AF202922; BC000270; BC003188; BC007297; BC008316 

Genbank Nucleotide ID

 AAF15294.2; AAH00270.2; AAH03188.1; AAH07297.1; AAH08316.1 

Protein Name

 O-acetyl-ADP-ribose deacetylase MACROD1 

Protein Synonyms/Alias

 MACRO domain-containing protein 1; Protein LRP16; [Protein ADP-ribosylglutamate] hydrolase 

Gene Name

 MACROD1 

Gene Synonyms/Alias

 LRP16 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	KEAKSFLKGLSDKQR	acetylation	[1]
163	LLRSDITKLEVDAIV	acetylation	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity. 

Sequence Annotation

 DOMAIN 141 322 Macro.
 REGION 159 161 Substrate binding (By similarity).
 REGION 172 174 Substrate binding (By similarity).
 REGION 179 184 Substrate binding (By similarity).
 REGION 267 273 Substrate binding (Probable).
 BINDING 306 306 Substrate (By similarity).  

Keyword

 3D-structure; Chromosomal rearrangement; Complete proteome; DNA damage; Hydrolase; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0019213; F:deacetylase activity; IDA:UniProtKB.
 GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IDA:UniProtKB.
 GO:0051725; P:protein de-ADP-ribosylation; IDA:UniProtKB.
 GO:0042278; P:purine nucleoside metabolic process; IDA:UniProtKB.
 GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB. 

Interpro

 IPR002589; A1pp. 

Pfam

 PF01661; Macro 

SMART

 SM00506; A1pp 

PROSITE

 PS51154; MACRO 

PRINTS