UniProt Accession

 PPAC_RAT; P41498; Q9R138 

Genbank Protein ID

 AF171072; BC062229 

Genbank Nucleotide ID

 AAD50990.1; AAH62229.1 

Protein Name

 Low molecular weight phosphotyrosine protein phosphatase 

Protein Synonyms/Alias

 LMW-PTP; LMW-PTPase; Low molecular weight cytosolic acid phosphatase 

Gene Name

 Acp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
113	QVKNCKAKIELLGSY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. 

Sequence Annotation

 ACT_SITE 13 13 Nucleophile (By similarity).
 ACT_SITE 19 19 By similarity.
 ACT_SITE 130 130 Proton donor (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 132 132 Phosphotyrosine (By similarity).
 MOD_RES 133 133 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 158 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0003993; F:acid phosphatase activity; IDA:RGD.
 GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0004725; F:protein tyrosine phosphatase activity; IDA:RGD.
 GO:0017124; F:SH3 domain binding; IDA:RGD.
 GO:0007268; P:synaptic transmission; IEP:RGD. 

Interpro

 IPR023485; Ptyr_pPase_SF.
 IPR002115; Tyr_Pase_low_mol_wt_mml.
 IPR000106; Tyr_phospatase/Ars_reductase.
 IPR017867; Tyr_phospatase_low_mol_wt. 

Pfam

 PF01451; LMWPc 

SMART

 SM00226; LMWPc 

PROSITE

  

PRINTS

 PR00719; LMWPTPASE.
 PR00720; MAMMALPTPASE.