CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039983
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Signal recognition particle subunit SRP68 
Protein Synonyms/Alias
  
Gene Name
 SRP68 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
11RHKFTGKKVTEELLTubiquitination[1]
41WSYAMQLKQEANTEPubiquitination[1, 2, 3, 4]
104RFEHQEWKAAIEAFNubiquitination[2, 3, 4]
119KCKTIYEKLASAFTEubiquitination[1, 2, 3, 4, 5]
176TEGLLAEKLEALITQubiquitination[1, 2, 3, 4]
187LITQTRAKQAATMSEubiquitination[1, 4, 6]
232QAESEETKERLFESMubiquitination[1, 4, 5]
259EELKPDQKQRDYILEubiquitination[1]
271ILEGEPGKVSNLQYLubiquitination[1]
299KRNENMAKGLQRALLubiquitination[4]
315QQPEDDSKRSPRPQDubiquitination[1, 3, 4, 5, 6]
356FQKEIGLKTLVFKAYubiquitination[1]
390VLYDRVLKYANEVNSacetylation[7]
390VLYDRVLKYANEVNSubiquitination[1]
403NSDAGAFKNSLKDLPubiquitination[1, 2, 3, 4, 5]
407GAFKNSLKDLPDVQEubiquitination[1, 5]
423ITQVRSEKCSLQAAAubiquitination[3]
451SSQVKDNKPLVERFEubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MGNRHKFTGK KVTEELLTDN RYLLLVLMDA ERAWSYAMQL KQEANTEPRK RFHLLSRLRK 60
AVKHAEELER LCESNRVDAK TKLEAQAYTA YLSGMLRFEH QEWKAAIEAF NKCKTIYEKL 120
ASAFTEEQAV LYNQRVEEIS PNIRYCAYNI GDQSAINELM QMRLRSGGTE GLLAEKLEAL 180
ITQTRAKQAA TMSEVEWRGR TVPVKIDKVR IFLLGLADNE AAIVQAESEE TKERLFESML 240
SECRDAIQVV REELKPDQKQ RDYILEGEPG KVSNLQYLHS YLTYIKLSTA IKRNENMAKG 300
LQRALLQQQP EDDSKRSPRP QDLIRLYDII LQNLVELLQL PGLEEDKAFQ KEIGLKTLVF 360
KAYRCFFIAQ SYVLVKKWSE ALVLYDRVLK YANEVNSDAG AFKNSLKDLP DVQELITQVR 420
SEKCSLQAAA ILDANDAHQT ETSSSQVKDN KPLVERFETF CLDPSLVTKQ ANLVHFPPGF 480
QPIPCKPLFF DLALNHVAFP PLEDKLEQKT KSGLTGYIKG IFGFRS 526 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:InterPro.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
 GO:0005047; F:signal recognition particle binding; IEA:InterPro.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. 
Interpro
 IPR026258; SRP68. 
Pfam
  
SMART
  
PROSITE
  
PRINTS