CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022668
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DnaJ homolog subfamily B member 2 
Protein Synonyms/Alias
 DnaJ homolog subfamily B member 10; mDj8 
Gene Name
 Dnajb2 
Gene Synonyms/Alias
 Dnajb10 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
26IKKAYRKKALQWHPDubiquitination[1]
34ALQWHPDKNPDNKEFubiquitination[1]
47EFAEKKFKEVAEAYEubiquitination[1]
59AYEVLSDKHKREIYDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
 DOMAIN 3 69 J.
 REPEAT 207 226 UIM 1.
 REPEAT 250 269 UIM 2.  
Keyword
 Alternative splicing; Chaperone; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 277 AA 
Protein Sequence
MASYYEILDV PRSASPDDIK KAYRKKALQW HPDKNPDNKE FAEKKFKEVA EAYEVLSDKH 60
KREIYDRYGR EGLTGAGSGP SRSETGGAGP GFTFTFRSPE EVFREFFGSG DPFSELFDDL 120
GVFSELQNQG PRLTGPFFTF SSSFPANSDF SSSSFSFSPG AGAFRSVSTS TTFVQGRRIT 180
TRRIMENGQE RVEVEEDGQL KSVSINGVPD DLALGLELSR REQQPSVAPG LGVMQVRPTS 240
LSRPPDHDLS EDEDLQLAMA YSLSEMEAAG QKPADVF 277 
Gene Ontology
 GO:0016234; C:inclusion body; IEA:Compara.
 GO:0000502; C:proteasome complex; IEA:Compara.
 GO:0030433; P:ER-associated protein catabolic process; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
 GO:0090084; P:negative regulation of inclusion body assembly; IEA:Compara.
 GO:0090086; P:negative regulation of protein deubiquitination; IEA:Compara.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Compara.
 GO:0031398; P:positive regulation of protein ubiquitination; IEA:Compara. 
Interpro
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR003903; Ubiquitin-int_motif. 
Pfam
 PF00226; DnaJ 
SMART
 SM00271; DnaJ
 SM00726; UIM 
PROSITE
 PS00636; DNAJ_1
 PS50076; DNAJ_2
 PS50330; UIM 
PRINTS
 PR00625; JDOMAIN.