Tag | Content |
---|
CPLM ID | CPLM-016445 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lymphatic vessel endothelial hyaluronic acid receptor 1 |
Protein Synonyms/Alias | LYVE-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1 |
Gene Name | Lyve1 |
Gene Synonyms/Alias | Crsbp1; Xlkd1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
277 | QKEMIETKVVKEEKA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. |
Sequence Annotation | DOMAIN 39 129 Link. CARBOHYD 52 52 N-linked (GlcNAc...). CARBOHYD 129 129 N-linked (GlcNAc...) (Potential). DISULFID 60 127 By similarity. DISULFID 84 105 By similarity. |
Keyword | Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 318 AA |
Protein Sequence | MLQHTSLVLL LASIWTTRHP VQGADLVQDL SISTCRIMGV ALVGRNKNPQ MNFTEANEAC 60 KMLGLTLASR DQVESAQKSG FETCSYGWVG EQFSVIPRIF SNPRCGKNGK GVLIWNAPSS 120 QKFKAYCHNS SDTWVNSCIP EIVTTFYPVL DTQTPATEFS VSSSAYLASS PDSTTPVSAT 180 TRAPPLTSMA RKTKKICITE VYTEPITMAT ETEAFVASGA AFKNEAAGFG GVPTALLVLA 240 LLFFGAAAVL AVCYVKRYVK AFPFTTKNQQ KEMIETKVVK EEKADDVNAN EESKKTIKNP 300 EEAKSPPKTT VRCLEAEV 318 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:MGI. GO:0005540; F:hyaluronic acid binding; IDA:MGI. GO:0004888; F:transmembrane signaling receptor activity; IDA:MGI. GO:0007155; P:cell adhesion; IEA:InterPro. GO:0006027; P:glycosaminoglycan catabolic process; IDA:MGI. GO:0006810; P:transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |