UniProt Accession

 NFIP1_RAT; Q5U2S1 

Genbank Protein ID

 BC085887 

Genbank Nucleotide ID

 AAH85887.1 

Protein Name

 NEDD4 family-interacting protein 1 

Protein Synonyms/Alias

  

Gene Name

 Ndfip1 

Gene Synonyms/Alias

 N4wbp5 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
63	KDESGFPKPPSYNVA	ubiquitination	[1]
83	YDEAERTKAEATIPL	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (By similarity). 

Sequence Annotation

 MOTIF 40 42 PY 1.
 MOTIF 65 67 PY 2.
 MOTIF 74 76 PY 3.  

Keyword

 Complete proteome; Endosome; Golgi apparatus; Membrane; Reference proteome; Repeat; Secreted; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0006879; P:cellular iron ion homeostasis; IEA:Compara.
 GO:0010629; P:negative regulation of gene expression; IEA:Compara.
 GO:0050728; P:negative regulation of inflammatory response; IEA:Compara.
 GO:0032713; P:negative regulation of interleukin-4 production; IEA:Compara.
 GO:0048294; P:negative regulation of isotype switching to IgE isotypes; IEA:Compara.
 GO:0051224; P:negative regulation of protein transport; IEA:Compara.
 GO:0042130; P:negative regulation of T cell proliferation; IEA:Compara.
 GO:0032410; P:negative regulation of transporter activity; IEA:Compara.
 GO:0002829; P:negative regulation of type 2 immune response; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0045732; P:positive regulation of protein catabolic process; IEA:Compara.
 GO:0031398; P:positive regulation of protein ubiquitination; IEA:Compara.
 GO:0048302; P:regulation of isotype switching to IgG isotypes; IEA:Compara.
 GO:0045619; P:regulation of lymphocyte differentiation; IEA:Compara.
 GO:0002761; P:regulation of myeloid leukocyte differentiation; IEA:Compara.
 GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:Compara. 

Interpro

 IPR019325; NEDD4/BSD2. 

Pfam

 PF10176; DUF2370 

SMART

  

PROSITE

  

PRINTS