CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017091
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 192 
Protein Synonyms/Alias
  
Gene Name
 TMEM192 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
201IRRFNKAKPEPDILEubiquitination[1]
246GDTIEYLKRHNALLSubiquitination[1]
254RHNALLSKRLLALTSubiquitination[2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 MOD_RES 15 15 Phosphothreonine.
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 213 213 Phosphotyrosine.  
Keyword
 Alternative splicing; Complete proteome; Endosome; Lysosome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 271 AA 
Protein Sequence
MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII VNLLWFIHLV 60
FVVLAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK VILWILHLLL ECYIQYHHSK 120
IRNRGYNLIY RSTRHLKRLA LMIQSSGNTV LLLILCMQHS FPEPGRLYLD LILAILALEL 180
ICSLICLLIY TVKIRRFNKA KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD 240
TIEYLKRHNA LLSKRLLALT SSDLGCQPSR T 271 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS