UniProt Accession

 CLC1_YEAST; P17891; D6VUV0 

Genbank Protein ID

 X52272; Z72952; Z72953; AY558272; BK006941 

Genbank Nucleotide ID

 CAA36515.1; CAA97192.1; CAA97193.1; AAS56598.1; DAA08261.1 

Protein Name

 Clathrin light chain 

Protein Synonyms/Alias

 CLC 

Gene Name

 CLC1 

Gene Synonyms/Alias

 YGR167W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
138	EIHEKDLKDEELKKE	acetylation	[1]
152	ELQDEAIKHIDDFYD	acetylation	[1]
165	YDSYNKKKEQQLEDA	ubiquitination	[2]
229	LRLKGNAKAPGA***	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi. The yeast light chain is important for cell growth. The light chain may help to properly orient the assembly/ disassembly of the clathrin coats. 

Sequence Annotation

 REGION 144 204 Involved in binding clathrin heavy chain
 MOD_RES 49 49 Phosphothreonine.
 MOD_RES 52 52 Phosphoserine.  

Keyword

 Calcium; Calmodulin-binding; Coated pit; Coiled coil; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 233 AA 

Protein Sequence

Gene Ontology

 GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
 GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
 GO:0030125; C:clathrin vesicle coat; TAS:SGD.
 GO:0005198; F:structural molecule activity; TAS:SGD.
 GO:0006897; P:endocytosis; IDA:SGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 

Interpro

 IPR000996; Clathrin_L-chain. 

Pfam

 PF01086; Clathrin_lg_ch 

SMART

  

PROSITE

 PS00224; CLATHRIN_LIGHT_CHN_1
 PS00581; CLATHRIN_LIGHT_CHN_2 

PRINTS