UniProt Accession

 COX41_RAT; P10888 

Genbank Protein ID

 X14209; X15029; J05425; X54081; BC084719 

Genbank Nucleotide ID

 CAA32426.1; CAA33133.1; AAA40949.1; CAA38018.1; AAH84719.1 

Protein Name

 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial 

Protein Synonyms/Alias

 Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1; COX IV-1 

Gene Name

 Cox4i1 

Gene Synonyms/Alias

 Cox4; Cox4a 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
29	RAHGSVVKSEDYALP	acetylation	[1]
53	LPDVAHVKLLSASQK	acetylation	[1]
60	KLLSASQKALKEKEK	acetylation	[1]
65	SQKALKEKEKADWSS	acetylation	[1]
67	KALKEKEKADWSSLS	acetylation	[1]
78	SSLSRDEKVQLYRIQ	acetylation	[1]
95	ESFAEMNKGTNEWKT	acetylation	[1]
149	TKRMLDMKVNPIQGF	acetylation	[1]
159	PIQGFSAKWDYNKNE	acetylation	[1]
164	SAKWDYNKNEWKK**	acetylation	[1]
168	DYNKNEWKK******	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 

Sequence Annotation

 MOD_RES 53 53 N6-acetyllysine (By similarity).
 MOD_RES 60 60 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 169 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
 GO:0007584; P:response to nutrient; IEP:RGD. 

Interpro

 IPR013288; Cyt_c_oxidase_su4.
 IPR004203; Cyt_c_oxidase_su4_fam. 

Pfam

 PF02936; COX4 

SMART

  

PROSITE

  

PRINTS

 PR01873; CYTCOXIDASE4.