CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033416
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase RNF123 
Protein Synonyms/Alias
  
Gene Name
 RNF123 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18RLAAILAKHFADARIubiquitination[1, 2]
398NQHLMNNKDCFFCKTubiquitination[2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 426 AA 
Protein Sequence
MEHGYEETLT RLAAILAKHF ADARIVGTDI RDSLMQALAS YVCYPHSLRA VERIPEEQRI 60
AMVRNLLAPY EQRPWAQTNW ILVRLWRGCG FGYRYTRLPH LLKTKLEDAN LPSLQKPCPS 120
TLLQQHMADL LQQGPDVAPS FLNSVLNQLN WAFSEFIGMI QEIQQAAERL ERNFVDSRQL 180
KVCATCFDLS VSLLRVLEMT ITLVPEIFLD WTRPTSEMLL RRLAQLLNQV LNRVTAERNL 240
FDRVVTLRLP GLESVDHYPI LVAVTGILVQ LLVRGPASER EQATSVLLAD PCFQLRSICY 300
LLGQPEPPAP GTALPAPDRK RFSLQSYADY ISADELAQVE QMLAHLTSAS AQAAAASLPT 360
SEEDLCPICY AHPISAVFQP CGHKSCKACI NQHLMNNKDC FFCKTTIVSV EDWEKGANTS 420
TTSSAA 426 
Gene Ontology
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
  
SMART
 SM00184; RING 
PROSITE
 PS50089; ZF_RING_2 
PRINTS