CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002524
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Epoxide hydrolase 1 
Protein Synonyms/Alias
 Epoxide hydratase; Microsomal epoxide hydrolase 
Gene Name
 Ephx1 
Gene Synonyms/Alias
 Eph-1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
91GFNSNYMKKVVSYWRacetylation[1]
119QYPHFKTKIEGLDIHacetylation[1]
131DIHFIHVKPPQLPSGacetylation[1]
334EKFSTWTKSEYRELEacetylation[1]
375VSSQRYYKENLGQGIacetylation[1]
386GQGIMVHKHEGMKVFacetylation[1]
419WVKVKYPKLISYSYMacetylation[1]
439FAAFEEPKLLAQDIRacetylation[1]
447LLAQDIRKFVSLAELacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. 
Sequence Annotation
 MOD_RES 295 295 Omega-N-methylated arginine.  
Keyword
 Aromatic hydrocarbons catabolism; Complete proteome; Detoxification; Endoplasmic reticulum; Hydrolase; Membrane; Methylation; Microsome; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 455 AA 
Protein Sequence
MWLELVLASL LGFVIYWFVS RDKEETLPLG DGWWGPGSKP SAKEDESIRP FKVETSDEEI 60
KDLHQRIDRF RASPPLEGSR FHYGFNSNYM KKVVSYWRNE FDWRKQVEIL NQYPHFKTKI 120
EGLDIHFIHV KPPQLPSGRT PKPLLMVHGW PGSFYEFYKI IPLLTDPKSH GLSDEHVFEV 180
ICPSIPGYGY SEASSKKGLN SVATARIFYK LMTRLGFQKF YIQGGDWGSL ICTNMAQMVP 240
NHVKGLHLNM AFISRSFYTM TPLLGQRFGR FLGYTEKDIE LLYPYKEKVF YSIMRESGYL 300
HIQATKPDTV GCALNDSPVG LAAYILEKFS TWTKSEYREL EDGGLERKFS LDDLLVNIMI 360
YWTTGTIVSS QRYYKENLGQ GIMVHKHEGM KVFVPTGFSA FPSELLHAPE KWVKVKYPKL 420
ISYSYMERGG HFAAFEEPKL LAQDIRKFVS LAELQ 455 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
 GO:0033961; F:cis-stilbene-oxide hydrolase activity; IEA:EC.
 GO:0004301; F:epoxide hydrolase activity; IDA:RGD.
 GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
 GO:0006805; P:xenobiotic metabolic process; TAS:RGD. 
Interpro
 IPR000073; AB_hydrolase_1.
 IPR000639; Epox_hydrolase-like.
 IPR010497; Epoxide_hydro_N.
 IPR016292; Epoxide_hydrolase. 
Pfam
 PF00561; Abhydrolase_1
 PF06441; EHN 
SMART
  
PROSITE
  
PRINTS
 PR00412; EPOXHYDRLASE.