CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018252
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Abhydrolase domain-containing protein 3 
Protein Synonyms/Alias
 Lung alpha/beta hydrolase 3 
Gene Name
 ABHD3 
Gene Synonyms/Alias
 LABH3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55YLSSIAKKPQLVTGGubiquitination[1]
102LRPFITSKPPVQYRNubiquitination[1, 2, 3]
288KHRHMFVKQVDMDHVubiquitination[1, 2, 3, 4, 5]
332ASPSPRLKSVGIPVLubiquitination[1, 2]
395TYMDRVFKQFVQAMVubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
 ACT_SITE 220 220 Charge relay system (By similarity).
 ACT_SITE 346 346 Charge relay system (By similarity).
 ACT_SITE 375 375 Charge relay system (By similarity).  
Keyword
 Complete proteome; Hydrolase; Membrane; Polymorphism; Reference proteome; Serine esterase; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 409 AA 
Protein Sequence
MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS SIAKKPQLVT 60
GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT SKPPVQYRNE LIKTADGGQI 120
SLDWFDNDNS TCYMDASTRP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA 180
GENLLTPRTY CCANTEDLET VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM 240
AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS 300
IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP SHAIPIETAK 360
QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELS 409 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW. 
Interpro
 IPR012020; AB-Hydro_YheT.
 IPR000952; UPF0017_hydro-like_CS. 
Pfam
  
SMART
  
PROSITE
 PS01133; UPF0017 
PRINTS