UniProt Accession

 PRDX6_RAT; O35244 

Genbank Protein ID

 AF014009; Y17295 

Genbank Nucleotide ID

 AAB66341.1; CAA76732.1 

Protein Name

 Peroxiredoxin-6 

Protein Synonyms/Alias

 1-Cys peroxiredoxin; 1-Cys PRX; Acidic calcium-independent phospholipase A2; aiPLA2; Antioxidant protein 2; Non-selenium glutathione peroxidase; NSGPx; Thiol-specific antioxidant protein 

Gene Name

 Prdx6 

Gene Synonyms/Alias

 Aipla2; Aop2; Tsa 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
56	TELGRAAKLAPEFAK	acetylation	[1]
63	KLAPEFAKRNVKLIA	acetylation	[1]
97	NGAAPTEKLPFPIID	acetylation	[1]
141	VFIFGPDKKLKLSIL	acetylation	[1]
182	VATPVDWKKGESVMV	acetylation	[1]
204	EAKQLFPKGVFTKEL	acetylation	[1]
209	FPKGVFTKELPSGKK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. 

Sequence Annotation

 DOMAIN 5 169 Thioredoxin.
 ACT_SITE 32 32 For phospholipase activity (By
 ACT_SITE 47 47 Cysteine sulfenic acid (-SOH)
 MOD_RES 44 44 Phosphothreonine (By similarity).
 MOD_RES 63 63 N6-acetyllysine (By similarity).
 MOD_RES 89 89 Phosphotyrosine (By similarity).
 MOD_RES 209 209 N6-acetyllysine (By similarity).
 DISULFID 47 47 Interchain; in linked form (By  

Keyword

 Acetylation; Antioxidant; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Lipid metabolism; Lysosome; Multifunctional enzyme; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 224 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0004602; F:glutathione peroxidase activity; IDA:RGD.
 GO:0051920; F:peroxiredoxin activity; IEA:EC.
 GO:0004623; F:phospholipase A2 activity; IEA:Compara.
 GO:0042744; P:hydrogen peroxide catabolic process; IDA:RGD.
 GO:0009395; P:phospholipid catabolic process; IEA:Compara. 

Interpro

 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR019479; Peroxiredoxin_C.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF10417; 1-cysPrx_C
 PF00578; AhpC-TSA 

SMART

  

PROSITE

 PS51352; THIOREDOXIN_2 

PRINTS