UniProt Accession

 RAB3A_MOUSE; P63011; P05713; Q3TSL4 

Genbank Protein ID

 X72966; AK005362; AK158727; AK161975; BC053519 

Genbank Nucleotide ID

 CAA51470.1; BAB23976.1; BAE34630.1; BAE36661.1; AAH53519.1 

Protein Name

 Ras-related protein Rab-3A 

Protein Synonyms/Alias

  

Gene Name

 Rab3a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
12	TDSRYGQKESSDQNF	ubiquitination	[1]
136	QVLLVGNKCDMEDER	ubiquitination	[1]
167	EFFEASAKDNINVKQ	ubiquitination	[1]
173	AKDNINVKQTFERLV	ubiquitination	[1]
186	LVDVICEKMSESLDT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). 

Sequence Annotation

 NP_BIND 29 36 GTP (By similarity).
 NP_BIND 48 54 GTP (By similarity).
 NP_BIND 77 81 GTP (By similarity).
 NP_BIND 135 138 GTP (By similarity).
 MOTIF 51 59 Effector region (By similarity).
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 188 188 Phosphoserine.
 MOD_RES 220 220 Cysteine methyl ester (By similarity).
 LIPID 218 218 S-geranylgeranyl cysteine (By
 LIPID 220 220 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Complete proteome; Direct protein sequencing; Exocytosis; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 220 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IDA:MGI.
 GO:0001671; F:ATPase activator activity; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:Compara.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0030324; P:lung development; IMP:MGI.
 GO:0048790; P:maintenance of presynaptic active zone structure; IMP:MGI.
 GO:0007005; P:mitochondrion organization; IMP:MGI.
 GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0031630; P:regulation of synaptic vesicle fusion to presynaptic membrane; IMP:MGI.
 GO:0003016; P:respiratory system process; IMP:MGI.
 GO:0051602; P:response to electrical stimulus; IMP:MGI.
 GO:0050975; P:sensory perception of touch; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0016079; P:synaptic vesicle exocytosis; IMP:MGI.
 GO:0016188; P:synaptic vesicle maturation; IMP:MGI. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.