| Tag | Content |
|---|
| CPLM ID | CPLM-002190 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Band 3 anion transport protein |
Protein Synonyms/Alias | Anion exchange protein 1; AE 1; Anion exchanger 1; MEB3; Solute carrier family 4 member 1; CD233 |
Gene Name | Slc4a1 |
Gene Synonyms/Alias | Ae1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 188 | LGNLEGVKPAVLTRS | ubiquitination | [1] | | 252 | GRANFLEKPVLGFVR | ubiquitination | [1] | | 353 | LNLVPVQKELLRRRY | ubiquitination | [1] | | 366 | RYLPSPAKPDPNLYN | ubiquitination | [1] | | 381 | TLDLNGGKGGPGDED | ubiquitination | [1] | | 761 | NALTVMGKASGPGAA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin. |
Sequence Annotation | REGION 69 303 Globular (By similarity).
REGION 190 199 Interaction with ANK1 (By similarity).
REGION 317 370 Dimerization arm (By similarity).
REGION 423 929 Membrane (anion exchange).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 18 18 Phosphoserine.
MOD_RES 31 31 Phosphotyrosine (By similarity).
MOD_RES 363 363 Phosphoserine.
MOD_RES 372 372 Phosphotyrosine (By similarity).
MOD_RES 922 922 Phosphotyrosine (By similarity).
LIPID 861 861 S-palmitoyl cysteine (By similarity).
CARBOHYD 660 660 N-linked (GlcNAc...) (Probable). |
Keyword | Acetylation; Alternative splicing; Anion exchange; Complete proteome; Direct protein sequencing; Glycoprotein; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 929 AA |
Protein Sequence | MGDMRDHEEV LEIPDRDSEE ELENIIGQIA YRDLTIPVTE MQDPEALPTE QTATDYVPSS 60
TSTPHPSSGQ VYVELQELMM DQRNQELQWV EAAHWIGLEE NLREDGVWGR PHLSYLTFWS 120
LLELQKVFSK GTFLLGLAET SLAGVANHLL DCFIYEDQIR PQDREELLRA LLLKRSHAED 180
LGNLEGVKPA VLTRSGGASE PLLPHQPSLE TQLYCGQAEG GSEGPSTSGT LKIPPDSETT 240
LVLVGRANFL EKPVLGFVRL KEAVPLEDLV LPEPVGFLLV LLGPEAPHVD YTQLGRAAAT 300
LMTERVFRIT ASMAHNREEL LRSLESFLDC SLVLPPTDAP SEKALLNLVP VQKELLRRRY 360
LPSPAKPDPN LYNTLDLNGG KGGPGDEDDP LRRTGRIFGG LIRDIRRRYP YYLSDITDAL 420
SPQVLAAVIF IYFAALSPAV TFGGLLGEKT RNLMGVSELL ISTAVQGILF ALLGAQPLLV 480
LGFSGPLLVF EEAFFSFCES NNLEYIVGRA WIGFWLILLV MLVVAFEGSF LVQYISRYTQ 540
EIFSFLISLI FIYETFSKLI KIFQDYPLQQ TYAPVVMKPK PQGPVPNTAL FSLVLMAGTF 600
LLAMTLRKFK NSTYFPGKLR RVIGDFGVPI SILIMVLVDS FIKGTYTQKL SVPDGLKVSN 660
SSARGWVIHP LGLYRLFPTW MMFASVLPAL LVFILIFLES QITTLIVSKP ERKMIKGSGF 720
HLDLLLVVGM GGVAALFGMP WLSATTVRSV THANALTVMG KASGPGAAAQ IQEVKEQRIS 780
GLLVSVLVGL SILMEPILSR IPLAVLFGIF LYMGVTSLSG IQLFDRILLL FKPPKYHPDV 840
PFVKRVKTWR MHLFTGIQII CLAVLWVVKS TPASLALPFV LILTVPLRRL ILPLIFRELE 900
LQCLDGDDAK VTFDEENGLD EYDEVPMPV 929 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB. GO:0030863; C:cortical cytoskeleton; IDA:MGI. GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. GO:0030018; C:Z disc; ISS:UniProtKB. GO:0015301; F:anion:anion antiporter activity; ISS:UniProtKB. GO:0015108; F:chloride transmembrane transporter activity; IDA:UniProtKB. GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |