UniProt Accession

 PHOB_ECOLI; P0AFJ5; P08402; Q2MC27 

Genbank Protein ID

 X04026; U73857; U00096; AP009048 

Genbank Nucleotide ID

 CAA27659.1; AAB18123.1; AAC73502.1; BAE76179.1 

Protein Name

 Phosphate regulon transcriptional regulatory protein PhoB 

Protein Synonyms/Alias

  

Gene Name

 phoB 

Gene Synonyms/Alias

 b0399; JW0389 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
110	ITKPFSPKELVARIK	acetylation	[1]
161	EMGPTEFKLLHFFMT	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. 

Sequence Annotation

 DOMAIN 1 120 Response regulatory.
 MOD_RES 53 53 4-aspartylphosphate.  

Keyword

 3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphate transport; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Transport; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0001108; F:bacterial-type RNA polymerase holo enzyme binding; IMP:EcoCyc.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:GOC.
 GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
 GO:2000142; P:regulation of DNA-dependent transcription, initiation; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001867; Sig_transdc_resp-reg_C.
 IPR011879; Sig_transdc_resp-reg_PhoB.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00072; Response_reg
 PF00486; Trans_reg_C 

SMART

 SM00448; REC
 SM00862; Trans_reg_C 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS