CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025880
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MKIAA4062 protein 
Protein Synonyms/Alias
  
Gene Name
 Diap1 
Gene Synonyms/Alias
 mKIAA4062 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
524HELQVEMKKMENDFEubiquitination[1]
571KLTGEVAKLSKELEDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1285 AA 
Protein Sequence
GSGQPGASGV DKGSLAGANQ DMEPSGGGLG PGRGTRDKKK GRSPDELPAT GGDGGKHKKF 60
TLKRLMADEL ERFTSMRIKK EKEKPNSAHR NSSASYGDDP TAQSLQDISD EQVLVLFEQM 120
LVDMNLNEEK QQPLREKDIV IKREMVSQYL HTSKAGMNQK ESSRSAMMYI QELRSGLRDM 180
HLLSCLESLR VSLNNNPVSW VQTFGAEGLA SLLDILKRLH DEKEETSGNY DSRNQHEIIR 240
CLKAFMNNKF GIKTMLETEE GILLLVRAMD PAVPNMMIDA AKLLSALCIL PQPEDMNERV 300
LEAMTERAEM DEVERFQPLL DGLKSGTSIA LKVGCLQLIN ALITPAEELD FRVHIRSELM 360
RLGLHQVLQE LREIENEDMK VQLCVFDEQG DEDFFDLKGR LDDIRMEMDD FGEVFQIILN 420
TVKDSKAEPH FLSILQHLLL VRNDYEARPQ YYKLIEECVS QIVLHKNGTD PDFKCRHLQI 480
DIERLVDQMI DKTKVEKSEA KATELEKKLD SELTARHELQ VEMKKMENDF EQKLQDLQGE 540
KDALDSEKQQ ITAQKQDLEA EVSKLTGEVA KLSKELEDAK NEMASLSAVV VAPSVSSSAA 600
VPPAPPLPGD SGTVIPPPPP PPPLPGGVVP PSPPLPPGTC IPPPPPLPGG ACIPPPPQLP 660
GSAAIPPPPP LPGVASIPPP PPLPGATAIP PPPPLPGATA IPPPPPLPGG TGIPPPPPPL 720
PGSVGVPPPP PLPGGPGLPP PPPPFPGAPG IPPPPPGMGV PPPPPFGFGV PAAPVLPFGL 780
TPKKVYKPEV QLRRPNWSKF VAEDLSQDCF WTKVKEDRFE NNELFAKLTL AFSAQTKTSK 840
AKKDQEGGEE KKSVQKKKVK ELKVLDSKTA QNLSIFLGSF RMPYQEIKNV ILEVNEAVLT 900
ESMIQNLIKQ MPEPEQLKML SELKEEYDDL AESEQFGVVM GTVPRLRPRL NAILFKLQFS 960
EQVENIKPEI VSVTAACEEL RKSENFSSLL ELTLLVGNYM NAGSRNAGAF GFNISFLCKL 1020
RDTKSADQKM TLLHFLAELC ENDHPEVLKF PDELAHVEKA SRVSAENLQK SLDQMKKQIA 1080
DVERDVQNFP AATDEKDKFV EKMTSFVKDA QEQYNKLRMM HSNMETLYKE LGDYFVFDPK 1140
KLSVEEFFMD LHNFRNMFLQ AVKENQKRRE TEEKMRRAKL AKEKAEKERL EKQQKREQLI 1200
DMNAEGDETG VMDSLLEALQ SGAAFRRKRG PRQVNRKAGC AVTSLLASEL TKDDAMAPGP 1260
VKVPKKSEGV PTILEEAKEL VGRAS 1285 
Gene Ontology
 GO:0032587; C:ruffle membrane; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0005522; F:profilin binding; IDA:MGI.
 GO:0017048; F:Rho GTPase binding; IDA:MGI.
 GO:0030041; P:actin filament polymerization; IDA:MGI. 
Interpro
 IPR003104; Actin-bd_FH2/DRF_autoreg.
 IPR016024; ARM-type_fold.
 IPR014767; Diaphanous_autoregulatory.
 IPR010465; Drf_DAD.
 IPR010472; Drf_FH3.
 IPR010473; Drf_GTPase-bd.
 IPR015425; FH2_actin-bd.
 IPR009408; Formin_homology_1.
 IPR014768; GTPase-bd/formin_homology_3. 
Pfam
 PF06345; Drf_DAD
 PF06346; Drf_FH1
 PF06367; Drf_FH3
 PF06371; Drf_GBD
 PF02181; FH2 
SMART
 SM00498; FH2 
PROSITE
 PS51231; DAD
 PS51444; FH2
 PS51232; GBD_FH3 
PRINTS