UniProt Accession

 TAF12_HUMAN; Q16514; D3DPM5; Q15775; Q5T077 

Genbank Protein ID

 U57693; U57693; D50544; X84002; BT007031; AY206865; AL513497; CH471059; CH471059; BC011986 

Genbank Nucleotide ID

 AAC50600.1; AAC50601.1; BAA09112.1; CAA58826.1; AAP35678.1; AAO13491.1; CAI22291.1; EAX07682.1; EAX07683.1; AAH11986.1 

Protein Name

 Transcription initiation factor TFIID subunit 12 

Protein Synonyms/Alias

 Transcription initiation factor TFIID 20/15 kDa subunits; TAFII-20/TAFII-15; TAFII20/TAFII15 

Gene Name

 TAF12 

Gene Synonyms/Alias

 TAF15; TAF2J; TAFII20 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	LSNFSSIKPEPASTP	sumoylation	[1]
61	NNQVLTKKKLQDLVR	ubiquitination	[2]
114	KSSTLEVKDVQLHLE	ubiquitination	[2]

Reference

 [1] SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5.
 Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay RT, Oelgeschläger T.
 J Biol Chem. 2005 Mar 18;280(11):9937-45. [PMID: 15637059]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. 

Sequence Annotation

 MOD_RES 43 43 Phosphothreonine.
 MOD_RES 51 51 Phosphoserine.
 MOD_RES 59 59 Phosphothreonine.  

Keyword

 3D-structure; Alternative initiation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0000125; C:PCAF complex; IDA:UniProtKB.
 GO:0030914; C:STAGA complex; IDA:UniProtKB.
 GO:0005669; C:transcription factor TFIID complex; IDA:MGI.
 GO:0033276; C:transcription factor TFTC complex; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IDA:UniProtKB.
 GO:0043966; P:histone H3 acetylation; IDA:UniProtKB.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR009072; Histone-fold.
 IPR003228; TFIID_sub. 

Pfam

 PF03847; TFIID_20kDa 

SMART

  

PROSITE

  

PRINTS