UniProt Accession

 AZIN1_HUMAN; O14977; A6NCD5; Q6IBQ7; Q96D20 

Genbank Protein ID

 D88674; BT006858; CR456745; AP003354; CH471060; BC013420; BC019279; AF070634 

Genbank Nucleotide ID

 BAA23593.1; AAP35504.1; CAG33026.1; EAW91851.1; AAH13420.1; AAH19279.1; AAC25391.1 

Protein Name

 Antizyme inhibitor 1 

Protein Synonyms/Alias

 AZI; Ornithine decarboxylase antizyme inhibitor 

Gene Name

 AZIN1 

Gene Synonyms/Alias

 OAZI; OAZIN 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
47	FFVGDLGKIVKKHSQ	ubiquitination	[1, 2, 3]
50	GDLGKIVKKHSQWQN	ubiquitination	[2]
51	DLGKIVKKHSQWQNV	ubiquitination	[2, 3]
63	QNVVAQIKPFYTVKC	ubiquitination	[2, 3]
121	CKQVSQIKYAAKVGV	ubiquitination	[2]
125	SQIKYAAKVGVNILT	ubiquitination	[2]
140	CDNEIELKKIARNHP	ubiquitination	[2, 4]
141	DNEIELKKIARNHPN	ubiquitination	[2]
150	ARNHPNAKVLLHIAT	ubiquitination	[2, 3]
169	GGEEGNMKFGTTLKN	ubiquitination	[2, 3]
175	MKFGTTLKNCRHLLE	ubiquitination	[1, 2, 3, 4, 5, 6]
203	FHVSSACKESQVYVH	ubiquitination	[2, 4]
291	AVNIIAKKVVENDKF	ubiquitination	[2]
297	KKVVENDKFPSGVEK	ubiquitination	[1, 2]
327	VYGSFASKLSEDLNT	ubiquitination	[2, 3]
340	NTIPEVHKKYKEDEP	ubiquitination	[1, 2, 3]
341	TIPEVHKKYKEDEPL	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme. 

Sequence Annotation

  

Keyword

 Complete proteome; Polyamine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 448 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0004857; F:enzyme inhibitor activity; TAS:ProtInc.
 GO:0042978; F:ornithine decarboxylase activator activity; IEA:Compara.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-KW.
 GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR009006; Ala_racemase/Decarboxylase_C.
 IPR022643; De-COase2_C.
 IPR022657; De-COase2_CS.
 IPR022644; De-COase2_N.
 IPR000183; Orn/DAP/Arg_de-COase.
 IPR002433; Orn_de-COase. 

Pfam

 PF02784; Orn_Arg_deC_N
 PF00278; Orn_DAP_Arg_deC 

SMART

  

PROSITE

 PS00878; ODR_DC_2_1
 PS00879; ODR_DC_2_2 

PRINTS

 PR01179; ODADCRBXLASE.
 PR01182; ORNDCRBXLASE.