| Tag | Content |
|---|
| CPLM ID | CPLM-024362 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | BCL-6 corepressor-like protein 1 |
Protein Synonyms/Alias | BCoR-L1; BCoR-like protein 1 |
Gene Name | Bcorl1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1491 | ARRLIVNKNAGETLL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor (By similarity). |
Sequence Annotation | REPEAT 1493 1523 ANK 1.
REPEAT 1527 1556 ANK 2.
REPEAT 1560 1589 ANK 3.
MOD_RES 607 607 Phosphoserine (By similarity).
MOD_RES 1162 1162 Phosphoserine (By similarity). |
Keyword | ANK repeat; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1781 AA |
Protein Sequence | MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GGCQHFGSQE FCVSSSFSKV 60
ELTAVGSGSN ARGTNPDGNT TEKLGHRSED QSDDPQPKMD YVGNPAEAEG LLVPLSSPGD 120
GLKLPTPDST EASHSRANCS WTPLSTQMSK QVDCSPAGVK ALDSRHGVGE KNTFILATLG 180
TGVPVEGTLP LVTTNFSQLP APICPPAPGS ASGTPSVPDP FQVPLSVPAP VPHSGLVPVQ 240
VATSASAPSP PLAPAAPSVP TLISDSNPLS VSASVLVPVP VSAPHSVPVP LSAPAPTPLT 300
VSVSAPPLAL IQAPVPPSAP TLVLASVPTP VLAPMPASTP PAAPAPPSVP MPTPTPSSGP 360
PSTPTLIPAF APTPVPAPTP APIFTPAPTP MPAATPAAIP TSAPIPASFS LSRVCFPAAQ 420
APAMQKVPLS FQPGTVLTPN QPLVYIPPPS CGQPLSVATL PTTLGVSSTL TLPVLPSYLQ 480
DRCLPGVLAS PDLRSYPCAF SVARPLASDS KLVSLEVNRL SCTSPSSSTN SQPAPDGVPG 540
PLADTSLTTA SAKVLPTSQL LLPAPSGSSV PPHPSKMPGG TDQQTEGTSV TFSPLKSPPQ 600
LEREMASPPE CSEMPLDLSA KSNRQKLPLP NQRKTPPMPV LTPVHTSSKA LLSTVLSRSQ 660
RTTQAAGSNV TSCLGSTSSP FVIFPEMVRN GDPSTWVKNS TALISTIPGT YVGVANPVPA 720
SLLLNKDPNL GLNRDPRHLP KQEPISIIDQ GEPKSTSATC GKKGSQAGAE GQPSTVKSRY 780
TPARIAPGLP GCQTKELSLW KPTGLTNMYP RCSINGKPTS TQVLPVGWSP YHQASLLSIG 840
ISSAGQLTPS QGVPIRPTSI VSEFSGVSPL GSSETVHGLP EGQPRPGGPF APEQDAVTKN 900
KNCRIAAKPY EEQVNPVLLT LSPQSGTLAL SVQPSSGDMG VNQGSEESES HLCSDSTPKM 960
EGPQAACGLK LAGDTKPKNQ VLATYMSHEL VLANPQNLCK MPELPLLPHD SHSKELILDV 1020
VPSSERGPST DLSQLGSQVD LGRVKMEKAD GDVVFNLANC FRADGLPAVP QRGQAEARAN 1080
AGQARVKRES IGVFTCKNSW QPDEETESLP PKKVKCNKEK EIEEEPRQQP PPQPHDKPMV 1140
RSSLGSKCRK LPGDPQEPTK KSPRGALDSG KEHNGVRGKH KHRKPTKPES QPPGKRTDGH 1200
EEGSLEKKAK NSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF PTEEEEEVAP 1260
TPAKRRKVRK TQRDTQYRSH HAQDKTLLSQ GRRHLWRARE MPWRTEAARQ MWDTNEEEED 1320
DEEEGLVKRK KRRRQKSRKY QTGEYLIEQE EQRRKGRADS KARKQKTSSQ SSEHCLRNRN 1380
LLLSSKAQGI SDSPNGFLPD NLEEPACLEN PEKPSGKRKC KTKHMANASE EARSKGRWSQ 1440
QKTRSSKSPT PVKPTEPCTP SKYRSAGPEE ASESPTARQI PPEARRLIVN KNAGETLLQR 1500
AARLGYKDVV LYCLQKHSED VNHRDNAGYT ALHEACSRGW TDILNILLQH GANVNCSSQD 1560
GTRPVHDAVV NDNLETIWLL LSYGADPTLA TYSGQTAMKL ASSDNMKRFL SDHLSDLQGR 1620
AEGDPRASWD FYSSSVLEKK DGFACDLLHN PPGSAEQGDD SEQDDFMFEL SDKPLLPCYN 1680
LQVSVSRGPC NWFLFSDVLK RLKLSSRIFQ ARFPHLEITT LPKAEFYRQV ASSQLLSPAE 1740
RPGSLEDRSP PGSSETVELV QYEPELLRLL GSEVEYQSWS S 1781 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:Compara. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |