UniProt Accession

 NDRG2_RAT; Q8VBU2; Q8VBW2; Q8VI00; Q8VI01 

Genbank Protein ID

 AJ426424; AJ426425; AJ426426; AJ426427; AF334105; AF334106 

Genbank Nucleotide ID

 CAD19997.1; CAD19998.1; CAD19999.1; CAD20000.1; AAL73186.1; AAL73187.1 

Protein Name

 Protein NDRG2 

Protein Synonyms/Alias

 Antidepressant-related protein ADRG123; N-myc downstream-regulated gene 2 protein; NDRG1-related protein 

Gene Name

 Ndrg2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
13	EVQITEEKPLLPGQT	acetylation	[1]
13	EVQITEEKPLLPGQT	ubiquitination	[2]
61	VYGTPKPKRPAIFTY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor (By similarity). May be involved in dendritic cell and neuron differentiation. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 326 326 Phosphoserine (By similarity).
 MOD_RES 328 328 Phosphoserine (By similarity).
 MOD_RES 330 330 Phosphothreonine (By similarity).
 MOD_RES 332 332 Phosphoserine.
 MOD_RES 334 334 Phosphothreonine (By similarity).
 MOD_RES 335 335 Phosphoserine (By similarity).
 MOD_RES 338 338 Phosphoserine.
 MOD_RES 342 342 Phosphoserine (By similarity).
 MOD_RES 344 344 Phosphoserine (By similarity).
 MOD_RES 346 346 Phosphoserine (By similarity).
 MOD_RES 348 348 Phosphothreonine (By similarity).
 MOD_RES 350 350 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).
 MOD_RES 353 353 Phosphoserine (By similarity).
 MOD_RES 355 355 Phosphoserine (By similarity).
 MOD_RES 357 357 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Phosphoprotein; Reference proteome; Tumor suppressor; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 371 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0001818; P:negative regulation of cytokine production; IEA:Compara.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0090361; P:regulation of platelet-derived growth factor production; IEA:Compara.
 GO:0010574; P:regulation of vascular endothelial growth factor production; IEA:Compara.
 GO:0007165; P:signal transduction; IDA:RGD.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR004142; Ndr. 

Pfam

 PF03096; Ndr 

SMART

  

PROSITE

  

PRINTS