UniProt Accession

 NFS1_HUMAN; Q9Y697; B3KMA5; B4DXK9; E1P5R8; F5GYK5; Q6P0L8; Q9NTZ5; Q9Y481 

Genbank Protein ID

 AF097025; AK001470; AK302023; AL109827; AL357374; AL109827; AL357374; CH471077; CH471077; BC065560; AJ010952 

Genbank Nucleotide ID

 AAD09187.2; BAG50917.1; BAG63421.1; CAB87612.2; CAB87612.2; CAI20116.1; CAI20116.1; EAW76170.1; EAW76172.1; AAH65560.1; CAA09424.1 

Protein Name

 Cysteine desulfurase, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 NFS1 

Gene Synonyms/Alias

 NIFS; HUSSY-08 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
120	VTYLPVQKSGIIDLK	ubiquitination	[1]
188	PLDVNDMKIDLMSIS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. 

Sequence Annotation

 ACT_SITE 381 381 By similarity.
 MOD_RES 258 258 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Mitochondrion; Molybdenum cofactor biosynthesis; Nucleus; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 457 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:HGNC.
 GO:0005759; C:mitochondrial matrix; IDA:HGNC.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0031071; F:cysteine desulfurase activity; IDA:HGNC.
 GO:0042803; F:protein homodimerization activity; IDA:HGNC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006534; P:cysteine metabolic process; IEA:InterPro.
 GO:0018283; P:iron incorporation into metallo-sulfur cluster; IDA:HGNC.
 GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW.
 GO:0032324; P:molybdopterin cofactor biosynthetic process; TAS:Reactome.
 GO:0006461; P:protein complex assembly; TAS:ProtInc.
 GO:0000096; P:sulfur amino acid metabolic process; TAS:ProtInc.
 GO:0006767; P:water-soluble vitamin metabolic process; TAS:Reactome. 

Interpro

 IPR000192; Aminotrans_V/Cys_dSase.
 IPR020578; Aminotrans_V_PyrdxlP_BS.
 IPR010240; Cys_deSase.
 IPR016454; Cysteine_dSase_NifS.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 

Pfam

 PF00266; Aminotran_5 

SMART

  

PROSITE

 PS00595; AA_TRANSFER_CLASS_5 

PRINTS