CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001036
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aurora kinase B 
Protein Synonyms/Alias
 Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B 
Gene Name
 Aurkb 
Gene Synonyms/Alias
 Aik2; Aim1; Airk2; Ark2; Stk1; Stk12; Stk5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
207KVIHRDIKPENLLLGsumoylation[1]
Reference
 [1] SUMOylation modulates the function of Aurora-B kinase.
 Fernández-Miranda G, Pérez de Castro I, Carmena M, Aguirre-Portolés C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M.
 J Cell Sci. 2010 Aug 15;123(Pt 16):2823-33. [PMID: 20663916
Functional Description
 Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP. Phosphorylation of INCENP leads to increased AURKB activity. Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin and histone H3. A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres. Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis. AURKB is also required for kinetochore localization of BUB1 and SGOL1. Phosphorylation of p53/TP53 negatively regulates its transcriptional activity (By similarity). 
Sequence Annotation
 DOMAIN 82 332 Protein kinase.
 NP_BIND 88 96 ATP (By similarity).
 ACT_SITE 205 205 Proton acceptor (By similarity).
 BINDING 111 111 ATP (By similarity).
 MOD_RES 35 35 Phosphothreonine (By similarity).
 MOD_RES 237 237 Phosphothreonine; by autocatalysis (By  
Keyword
 ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Metal-binding; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 345 AA 
Protein Sequence
MAQKENAYPW PYGSKTSQSG LNTLSQRVLR KEPATTSALA LVNRFNSQST AAPGQKLAEN 60
KSQGSTASQG SQNKQPFTID NFEIGRPLGK GKFGNVYLAR EKKSRFIVAL KILFKSQIEK 120
EGVEHQLRRE IEIQAHLKHP NILQLYNYFY DQQRIYLILE YAPRGELYKE LQKSRTFDEQ 180
RTATIMEELS DALTYCHKKK VIHRDIKPEN LLLGLQGELK IADFGWSVHA PSLRRKTMCG 240
TLDYLPPEMI EGRMHNEMVD LWCIGVLCYE LMVGNPPFES PSHSETYRRI VKVDLKFPSS 300
VPSGAQDLIS KLLKHNPWQR LPLAEVAAHP WVRANSRRVL PPSAL 345 
Gene Ontology
 GO:0010369; C:chromocenter; IDA:MGI.
 GO:0032133; C:chromosome passenger complex; IDA:MGI.
 GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0000776; C:kinetochore; ISO:MGI.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0097431; C:mitotic spindle pole; ISO:MGI.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0007568; P:aging; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0034644; P:cellular response to UV; ISS:UniProtKB.
 GO:0036089; P:cleavage furrow formation; ISS:UniProtKB.
 GO:0002903; P:negative regulation of B cell apoptotic process; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0032467; P:positive regulation of cytokinesis; ISS:UniProtKB.
 GO:0034501; P:protein localization to kinetochore; ISS:UniProtKB.
 GO:0051256; P:spindle midzone assembly involved in mitosis; ISS:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS