CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010403
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leukotriene-B(4) omega-hydroxylase 1 
Protein Synonyms/Alias
 CYPIVF2; Cytochrome P450 4F2; Cytochrome P450-LTB-omega; Leukotriene-B(4) 20-monooxygenase 1 
Gene Name
 CYP4F2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
290VDDFLQAKAKSKTLDubiquitination[1]
292DFLQAKAKSKTLDFIacetylation[2]
294LQAKAKSKTLDFIDVacetylation[2]
306IDVLLLSKDEDGKKLubiquitination[1]
311LSKDEDGKKLSDEDIubiquitination[1]
346WVLYHLAKHPEYQERacetylation[2]
501DHTEPRRKPELVLRAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 468 468 Iron (heme axial ligand) (By similarity).
 BINDING 328 328 Heme (covalent; via 1 link) (By  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Oxidoreductase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MSQLSLSWLG LWPVAASPWL LLLLVGASWL LAHVLAWTYA FYDNCRRLRC FPQPPRRNWF 60
WGHQGMVNPT EEGMRVLTQL VATYPQGFKV WMGPISPLLS LCHPDIIRSV INASAAIAPK 120
DKFFYSFLEP WLGDGLLLSA GDKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 180
LASEGSACLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVSKRHHEIL 240
LHIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 300
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 360
LLKDREPKEI EWDDLAHLPF LTMCMKESLR LHPPVPVISR HVTQDIVLPD GRVIPKGIIC 420
LISVFGTHHN PAVWPDPEVY DPFRFDPENI KERSPLAFIP FSAGPRNCIG QTFAMAEMKV 480
VLALTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS 520 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB.
 GO:0018685; F:alkane 1-monooxygenase activity; IDA:BHF-UCL.
 GO:0052871; F:alpha-tocopherol omega-hydroxylase activity; IDA:UniProtKB.
 GO:0008392; F:arachidonic acid epoxygenase activity; IDA:UniProtKB.
 GO:0052869; F:arachidonic acid omega-hydroxylase activity; IDA:UniProtKB.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0050051; F:leukotriene-B4 20-monooxygenase activity; IDA:UniProtKB.
 GO:0052872; F:tocotrienol omega-hydroxylase activity; IDA:UniProtKB.
 GO:0047057; F:vitamin-K-epoxide reductase (warfarin-sensitive) activity; IMP:UniProtKB.
 GO:0017144; P:drug metabolic process; IMP:UniProtKB.
 GO:0019373; P:epoxygenase P450 pathway; IDA:UniProtKB.
 GO:0030195; P:negative regulation of blood coagulation; IMP:UniProtKB.
 GO:0032304; P:negative regulation of icosanoid secretion; IMP:UniProtKB.
 GO:0097267; P:omega-hydroxylase P450 pathway; TAS:Reactome.
 GO:0032305; P:positive regulation of icosanoid secretion; IMP:UniProtKB.
 GO:0003095; P:pressure natriuresis; IEP:UniProtKB.
 GO:0003091; P:renal water homeostasis; IEP:UniProtKB.
 GO:0055078; P:sodium ion homeostasis; IEP:UniProtKB.
 GO:0000038; P:very long-chain fatty acid metabolic process; IDA:BHF-UCL.
 GO:0042360; P:vitamin E metabolic process; IDA:UniProtKB.
 GO:0042371; P:vitamin K biosynthetic process; IMP:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.