| Tag | Content |
|---|
| CPLM ID | CPLM-023027 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ras GTPase-activating protein nGAP |
Protein Synonyms/Alias | RAS protein activator-like 2 |
Gene Name | RASAL2 |
Gene Synonyms/Alias | NGAP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 25 | SGTSTSEKPNSMDTA | acetylation | [1] | | 38 | TANTSPFKVPGFFSK | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Inhibitory regulator of the Ras-cyclic AMP pathway. |
Sequence Annotation | DOMAIN 41 158 PH.
DOMAIN 170 266 C2.
DOMAIN 327 519 Ras-GAP.
MOD_RES 16 16 Phosphoserine.
MOD_RES 89 89 Phosphoserine.
MOD_RES 663 663 Phosphoserine.
MOD_RES 864 864 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1139 AA |
Protein Sequence | MQTPEVPAER SPRRRSISGT STSEKPNSMD TANTSPFKVP GFFSKRLKGS IKRTKSQSKL 60
DRNTSFRLPS LRSTDDRSRG LPKLKESRSH ESLLSPCSTV ECLDLGRGEP VSVKPLHSSI 120
LGQDFCFEVT YLSGSKCFSC NSASERDKWM ENLRRTVQPN KDNCRRAENV LRLWIIEAKD 180
LAPKKKYFCE LCLDDTLFAR TTSKTKADNI FWGEHFEFFS LPPLHSITVH IYKDVEKKKK 240
KDKNNYVGLV NIPTASVTGR QFVEKWYPVS TPTPNKGKTG GPSIRIKSRF QTITILPMEQ 300
YKEFAEFVTS NYTMLCSVLE PVISVRNKEE LACALVHILQ STGRAKDFLT DLVMSEVDRC 360
GEHDVLIFRE NTIATKSIEE YLKLVGQQYL HDALGEFIKA LYESDENCEV DPSKCSSSEL 420
IDHQSNLKMC CELAFCKIIN SYCVFPRELK EVFASWKQQC LNRGKQDISE RLISASLFLR 480
FLCPAIMSPS LFNLMQEYPD DRTSRTLTLI AKVIQNLANF AKFGNKEEYM AFMNDFLEHE 540
WGGMKRFLLE ISNPDTISNT PGFDGYIDLG RELSVLHSLL WEVVSQLDKG ENSFLQATVA 600
KLGPLPRVLA DITKSLTNPT PIQQQLRRFT EHNSSPNVSG SLSSGLQKIF EDPTDSDLHK 660
LKSPSQDNTD SYFRGKTLLL VQQASSQSMT YSEKDERESS LPNGRSVSLM DLQDTHAAQV 720
EHASVMLDVP IRLTGSQLSI TQVASIKQLR ETQSTPQSAP QVRRPLHPAL NQPGGLQPLS 780
FQNPVYHLNN PIPAMPKASI DSSLENLSTA SSRSQSNSED FKLSGPSNSS MEDFTKRSTQ 840
SEDFSRRHTV PDRHIPLALP RQNSTGQAQI RKVDQGGLGA RAKAPPSLPH SASLRSTGSM 900
SVVSAALVAE PVQNGSRSRQ QSSSSRESPV PKVRAIQRQQ TQQVQSPVDS ATMSPVERTA 960
AWVLNNGQYE EDVEETEQNL DEAKHAEKYE QEITKLKERL RVSSRRLEEY ERRLLVQEQQ 1020
MQKLLLEYKA RLEDSEERLR RQQEEKDSQM KSIISRLMAV EEELKKDHAE MQAVIDAKQK 1080
IIDAQEKRIV SLDSANTRLM SALTQVKERY SMQVRNGISP TNPTKLSITE NGEFKNSSC 1139 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. GO:0007165; P:signal transduction; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |