UniProt Accession

 SARNP_RAT; Q498U4 

Genbank Protein ID

 BC100070 

Genbank Nucleotide ID

 AAI00071.1 

Protein Name

 SAP domain-containing ribonucleoprotein 

Protein Synonyms/Alias

 Nuclear protein Hcc-1 

Gene Name

 Sarnp 

Gene Synonyms/Alias

 Hcc1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
10	TETVELHKLKLAELK	acetylation	[1]
31	GLETKGIKQDLINRL	acetylation	[1]
88	VVDMASEKKVVKITS	acetylation	[1]
119	VPVSLESKKAARAAR	acetylation	[1]
135	GISSVPTKGLSSDTK	acetylation	[1]
142	KGLSSDTKPMVNLDK	acetylation	[1]
149	KPMVNLDKLKERAQR	acetylation	[1]
173	RKSEDDEKLKKRKER	acetylation	[1]
199	TTEDTEAKKRKRAER	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis (By similarity). 

Sequence Annotation

 DOMAIN 8 42 SAP.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 163 163 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Transcription; Transcription regulation; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003034; SAP_dom. 

Pfam

 PF02037; SAP 

SMART

 SM00513; SAP 

PROSITE

 PS50800; SAP 

PRINTS